Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated with increased risks of hematological malignancies. While TP53 mutations have been identified in CHIP, the molecular mechanisms by which mutant p53 promotes hematopoietic stem and progenitor cell (HSPC) expan...

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Detalles Bibliográficos
Autores principales: Chen, Sisi, Wang, Qiang, Yu, Hao, Capitano, Maegan L., Vemula, Sasidhar, Nabinger, Sarah C., Gao, Rui, Yao, Chonghua, Kobayashi, Michihiro, Geng, Zhuangzhuang, Fahey, Aidan, Henley, Danielle, Liu, Stephen Z., Barajas, Sergio, Cai, Wenjie, Wolf, Eric R., Ramdas, Baskar, Cai, Zhigang, Gao, Hongyu, Luo, Na, Sun, Yang, Wong, Terrence N., Link, Daniel C., Liu, Yunlong, Boswell, H. Scott, Mayo, Lindsey D., Huang, Gang, Kapur, Reuben, Yoder, Mervin C., Broxmeyer, Hal E., Gao, Zhonghua, Liu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906427/
https://www.ncbi.nlm.nih.gov/pubmed/31827082
http://dx.doi.org/10.1038/s41467-019-13542-2

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