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Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature
BACKGROUND: Micronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906565/ https://www.ncbi.nlm.nih.gov/pubmed/31832410 http://dx.doi.org/10.12998/wjcc.v7.i23.4063 |
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author | Wang, Bei Li, Kai Song, Qing-Kun Wang, Xiu-Hong Yang, Lei Zhang, Hong-Lei Zhong, Ding-Rong |
author_facet | Wang, Bei Li, Kai Song, Qing-Kun Wang, Xiu-Hong Yang, Lei Zhang, Hong-Lei Zhong, Ding-Rong |
author_sort | Wang, Bei |
collection | PubMed |
description | BACKGROUND: Micronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells. This type of tumor is rare; therefore, the corresponding clinical guidelines, histopathological diagnostic criteria, prognostic factors, and therapeutic regimens have not been established. CASE SUMMARY: This study covers a novel presentation of MNC in a patient and summarizes the clinicopathological characteristics of this type of tumor by using pooled-analysis methods. Morphologically, this tumor type is a series of benign to malignant pedigrees. We establish the following criteria for the classification of micronodular thymic tumors with lymphoid stroma: (1) Tumor cells with moderate-to-severe dysplasia; (2) Tumor cell mitotic figures > 2/10 high-power fields; (3) Appearance of neoplastic necrosis; (4) No terminal deoxynucleotidyl transferase-positive immature T lymphocytes within the tumor; (5) Tumor cells with a Ki-67 index ≥ 10%; and (6) Tumor cells express CD5. Cases that fall into the borders of two categories in terms of morphology are attributed to atypical MNT. It is proposed that the diagnosis of MNT should be established on the diagnostic criteria mentioned above. CONCLUSION: Our diagnostic algorithm can effectively distinguish malignant tumors from benign tumors and provides a potent basis for predicting a prognosis, which offers a practical reference for oncologists and pathologists. |
format | Online Article Text |
id | pubmed-6906565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-69065652019-12-12 Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature Wang, Bei Li, Kai Song, Qing-Kun Wang, Xiu-Hong Yang, Lei Zhang, Hong-Lei Zhong, Ding-Rong World J Clin Cases Case Report BACKGROUND: Micronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells. This type of tumor is rare; therefore, the corresponding clinical guidelines, histopathological diagnostic criteria, prognostic factors, and therapeutic regimens have not been established. CASE SUMMARY: This study covers a novel presentation of MNC in a patient and summarizes the clinicopathological characteristics of this type of tumor by using pooled-analysis methods. Morphologically, this tumor type is a series of benign to malignant pedigrees. We establish the following criteria for the classification of micronodular thymic tumors with lymphoid stroma: (1) Tumor cells with moderate-to-severe dysplasia; (2) Tumor cell mitotic figures > 2/10 high-power fields; (3) Appearance of neoplastic necrosis; (4) No terminal deoxynucleotidyl transferase-positive immature T lymphocytes within the tumor; (5) Tumor cells with a Ki-67 index ≥ 10%; and (6) Tumor cells express CD5. Cases that fall into the borders of two categories in terms of morphology are attributed to atypical MNT. It is proposed that the diagnosis of MNT should be established on the diagnostic criteria mentioned above. CONCLUSION: Our diagnostic algorithm can effectively distinguish malignant tumors from benign tumors and provides a potent basis for predicting a prognosis, which offers a practical reference for oncologists and pathologists. Baishideng Publishing Group Inc 2019-12-06 2019-12-06 /pmc/articles/PMC6906565/ /pubmed/31832410 http://dx.doi.org/10.12998/wjcc.v7.i23.4063 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Wang, Bei Li, Kai Song, Qing-Kun Wang, Xiu-Hong Yang, Lei Zhang, Hong-Lei Zhong, Ding-Rong Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature |
title | Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature |
title_full | Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature |
title_fullStr | Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature |
title_full_unstemmed | Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature |
title_short | Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature |
title_sort | micronodular thymic tumor with lymphoid stroma: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906565/ https://www.ncbi.nlm.nih.gov/pubmed/31832410 http://dx.doi.org/10.12998/wjcc.v7.i23.4063 |
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