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Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature

BACKGROUND: Pancreatic mixed serous-neuroendocrine neoplasms (MSNNs) are mixed tumors containing two components with different pathologies, namely, pancreatic serous cystic neoplasm (PSCN) and pancreatic neuroendocrine tumor (PanNET). For MSNNs, diffuse PSCN involving the whole pancreas is extremely...

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Autores principales: Xu, Yue-Mei, Li, Zhi-Wen, Wu, Hong-Yan, Fan, Xiang-Shan, Sun, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906574/
https://www.ncbi.nlm.nih.gov/pubmed/31832417
http://dx.doi.org/10.12998/wjcc.v7.i23.4119
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author Xu, Yue-Mei
Li, Zhi-Wen
Wu, Hong-Yan
Fan, Xiang-Shan
Sun, Qi
author_facet Xu, Yue-Mei
Li, Zhi-Wen
Wu, Hong-Yan
Fan, Xiang-Shan
Sun, Qi
author_sort Xu, Yue-Mei
collection PubMed
description BACKGROUND: Pancreatic mixed serous-neuroendocrine neoplasms (MSNNs) are mixed tumors containing two components with different pathologies, namely, pancreatic serous cystic neoplasm (PSCN) and pancreatic neuroendocrine tumor (PanNET). For MSNNs, diffuse PSCN involving the whole pancreas is extremely rare, with only eight previous case reports. CASE SUMMARY: A 45-year-old Chinese woman, with a free previous medical history and no obvious symptoms, was found to have a pancreatic neoplasm and admitted to our hospital for further diagnosis in March 2018. Abdominal palpation revealed a painless, mobile mass in the epigastrium, and no abnormalities were observed in an examination of the nervous system and ocular system. A computed tomography scan showed multiple cystic lesions involving the whole pancreas ranging in diameter from 0.4 to 2 cm and also revealed an enhanced mass, 2.2 cm in diameter, in the head of the pancreas. Moreover, multiple cysts were found in the kidneys bilaterally, and the right lobe of the liver contained a small cyst. A Whipple operation with total pancreatectomy and splenectomy was performed. A diagnosis of pancreatic MSNN was established, consisting of diffuse serous microcystic cystadenoma with a concomitant grade 2 PanNET. Of note, the patient had no personal or family history of Von Hippel-Lindau syndrome or other disease. CONCLUSION: We report the first case of MSNN with a diffuse PSCN component involving the entire pancreas in a Chinese woman. It is important to be aware of its relationship with VHL syndrome, and close clinical follow-up is recommended.
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spelling pubmed-69065742019-12-12 Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature Xu, Yue-Mei Li, Zhi-Wen Wu, Hong-Yan Fan, Xiang-Shan Sun, Qi World J Clin Cases Case Report BACKGROUND: Pancreatic mixed serous-neuroendocrine neoplasms (MSNNs) are mixed tumors containing two components with different pathologies, namely, pancreatic serous cystic neoplasm (PSCN) and pancreatic neuroendocrine tumor (PanNET). For MSNNs, diffuse PSCN involving the whole pancreas is extremely rare, with only eight previous case reports. CASE SUMMARY: A 45-year-old Chinese woman, with a free previous medical history and no obvious symptoms, was found to have a pancreatic neoplasm and admitted to our hospital for further diagnosis in March 2018. Abdominal palpation revealed a painless, mobile mass in the epigastrium, and no abnormalities were observed in an examination of the nervous system and ocular system. A computed tomography scan showed multiple cystic lesions involving the whole pancreas ranging in diameter from 0.4 to 2 cm and also revealed an enhanced mass, 2.2 cm in diameter, in the head of the pancreas. Moreover, multiple cysts were found in the kidneys bilaterally, and the right lobe of the liver contained a small cyst. A Whipple operation with total pancreatectomy and splenectomy was performed. A diagnosis of pancreatic MSNN was established, consisting of diffuse serous microcystic cystadenoma with a concomitant grade 2 PanNET. Of note, the patient had no personal or family history of Von Hippel-Lindau syndrome or other disease. CONCLUSION: We report the first case of MSNN with a diffuse PSCN component involving the entire pancreas in a Chinese woman. It is important to be aware of its relationship with VHL syndrome, and close clinical follow-up is recommended. Baishideng Publishing Group Inc 2019-12-06 2019-12-06 /pmc/articles/PMC6906574/ /pubmed/31832417 http://dx.doi.org/10.12998/wjcc.v7.i23.4119 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Xu, Yue-Mei
Li, Zhi-Wen
Wu, Hong-Yan
Fan, Xiang-Shan
Sun, Qi
Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature
title Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature
title_full Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature
title_fullStr Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature
title_full_unstemmed Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature
title_short Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature
title_sort mixed serous-neuroendocrine neoplasm of the pancreas: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906574/
https://www.ncbi.nlm.nih.gov/pubmed/31832417
http://dx.doi.org/10.12998/wjcc.v7.i23.4119
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