Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variant...

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Detalles Bibliográficos
Autores principales: Carvalho, Darlen Cardoso, Wanderley, Alayde Vieira, Mello Junior, Fernando Augusto Rodrigues, Santos, André Mauricio Ribeiro dos, Leitão, Luciana Pereira Colares, Souza, Tatiane Piedade de, Castro, Amanda de Nazaré Cohen Lima de, Magalhães, Leandro Lopes de, Fernandes, Marianne Rodrigues, Carvalho Junior, João Augusto Nunes de, Khayat, André Salim, Santos, Sidney, Assumpção, Paulo Pimentel de, dos Santos, Ney Pereira Carneiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906641/
https://www.ncbi.nlm.nih.gov/pubmed/31867206
http://dx.doi.org/10.1016/j.lrr.2019.100188
Descripción
Sumario:Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.

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