Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variant...

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Autores principales: Carvalho, Darlen Cardoso, Wanderley, Alayde Vieira, Mello Junior, Fernando Augusto Rodrigues, Santos, André Mauricio Ribeiro dos, Leitão, Luciana Pereira Colares, Souza, Tatiane Piedade de, Castro, Amanda de Nazaré Cohen Lima de, Magalhães, Leandro Lopes de, Fernandes, Marianne Rodrigues, Carvalho Junior, João Augusto Nunes de, Khayat, André Salim, Santos, Sidney, Assumpção, Paulo Pimentel de, dos Santos, Ney Pereira Carneiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906641/
https://www.ncbi.nlm.nih.gov/pubmed/31867206
http://dx.doi.org/10.1016/j.lrr.2019.100188
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author Carvalho, Darlen Cardoso
Wanderley, Alayde Vieira
Mello Junior, Fernando Augusto Rodrigues
Santos, André Mauricio Ribeiro dos
Leitão, Luciana Pereira Colares
Souza, Tatiane Piedade de
Castro, Amanda de Nazaré Cohen Lima de
Magalhães, Leandro Lopes de
Fernandes, Marianne Rodrigues
Carvalho Junior, João Augusto Nunes de
Khayat, André Salim
Santos, Sidney
Assumpção, Paulo Pimentel de
dos Santos, Ney Pereira Carneiro
author_facet Carvalho, Darlen Cardoso
Wanderley, Alayde Vieira
Mello Junior, Fernando Augusto Rodrigues
Santos, André Mauricio Ribeiro dos
Leitão, Luciana Pereira Colares
Souza, Tatiane Piedade de
Castro, Amanda de Nazaré Cohen Lima de
Magalhães, Leandro Lopes de
Fernandes, Marianne Rodrigues
Carvalho Junior, João Augusto Nunes de
Khayat, André Salim
Santos, Sidney
Assumpção, Paulo Pimentel de
dos Santos, Ney Pereira Carneiro
author_sort Carvalho, Darlen Cardoso
collection PubMed
description Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.
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spelling pubmed-69066412019-12-20 Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region Carvalho, Darlen Cardoso Wanderley, Alayde Vieira Mello Junior, Fernando Augusto Rodrigues Santos, André Mauricio Ribeiro dos Leitão, Luciana Pereira Colares Souza, Tatiane Piedade de Castro, Amanda de Nazaré Cohen Lima de Magalhães, Leandro Lopes de Fernandes, Marianne Rodrigues Carvalho Junior, João Augusto Nunes de Khayat, André Salim Santos, Sidney Assumpção, Paulo Pimentel de dos Santos, Ney Pereira Carneiro Leuk Res Rep Article Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population. Elsevier 2019-11-27 /pmc/articles/PMC6906641/ /pubmed/31867206 http://dx.doi.org/10.1016/j.lrr.2019.100188 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Carvalho, Darlen Cardoso
Wanderley, Alayde Vieira
Mello Junior, Fernando Augusto Rodrigues
Santos, André Mauricio Ribeiro dos
Leitão, Luciana Pereira Colares
Souza, Tatiane Piedade de
Castro, Amanda de Nazaré Cohen Lima de
Magalhães, Leandro Lopes de
Fernandes, Marianne Rodrigues
Carvalho Junior, João Augusto Nunes de
Khayat, André Salim
Santos, Sidney
Assumpção, Paulo Pimentel de
dos Santos, Ney Pereira Carneiro
Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_full Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_fullStr Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_full_unstemmed Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_short Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_sort association of genes arid5b, cebpe and folate pathway with acute lymphoblastic leukemia in a population from the brazilian amazon region
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906641/
https://www.ncbi.nlm.nih.gov/pubmed/31867206
http://dx.doi.org/10.1016/j.lrr.2019.100188
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