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Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats

Fibroblast proliferation and migration are central in atrial fibrillation (AF) promoting structure remodeling, which is strongly associated with aging and hypertension. Transient receptor potential canonical-3 channel (TRPC3) is a key mediator of cardiac fibrosis and the pathogenesis of AF. Here, we...

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Detalles Bibliográficos
Autores principales:	He, Rongfang, Zhang, Juan, Luo, Dan, Yu, Yiyan, Chen, Tangting, Yang, Yan, Yu, Fengxu, Li, Miaoling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906806/ https://www.ncbi.nlm.nih.gov/pubmed/31871548 http://dx.doi.org/10.1155/2019/4025496

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