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A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman
Primary benign neurogenic neoplasms of the pleura are exceedingly rare. Neurofibromas rarely involve the pleura. A review of the literarture reveals only a single reported case of isolated pleural neurofibroma. Herein the authors describe another case of isolated primary pleural neurofibroma. A 39-y...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906869/ https://www.ncbi.nlm.nih.gov/pubmed/31871813 http://dx.doi.org/10.1155/2019/6458302 |
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author | Krishnamurthy, Kritika Alexis, John Basra, Pukhraz Medina, Ana Maria |
author_facet | Krishnamurthy, Kritika Alexis, John Basra, Pukhraz Medina, Ana Maria |
author_sort | Krishnamurthy, Kritika |
collection | PubMed |
description | Primary benign neurogenic neoplasms of the pleura are exceedingly rare. Neurofibromas rarely involve the pleura. A review of the literarture reveals only a single reported case of isolated pleural neurofibroma. Herein the authors describe another case of isolated primary pleural neurofibroma. A 39-year-old nonsmoker woman presented to the emergency room with complaints of progressively worsening chest pain of one month duration. A computed tomography of the chest revealed a crescent shaped, pleural based mass suspicious for a neurogenic tumor such as an intercostal schwannoma. A PET-CT skull base to midthigh failed to reveal any other masses or abnormalities. A surgical excision of the mass was performed due to the patient's intractable pain. The resected specimen consisted of an ovoid fragment of soft tissue with pale yellow, smooth and glistening cut surface. Microscopic examination revealed the tumor to be composed of spindle cells with wavy nuclei arranged haphazardly in loose collagenous and pale myxoid stroma with rare interspersed mast cells. The spindle cells were diffusely positive for S100 protein and SOX-10, and focally positive for neurofilament. In the absence of any other masses in the patient and no pertinent history, a diagnosis of primary pleural neurofibroma was made. This case emphasizes the need to consider neurofibroma in any spindle cell neoplasm of the pleura irrespective of age or singularity. |
format | Online Article Text |
id | pubmed-6906869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-69068692019-12-23 A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman Krishnamurthy, Kritika Alexis, John Basra, Pukhraz Medina, Ana Maria Case Rep Pulmonol Case Report Primary benign neurogenic neoplasms of the pleura are exceedingly rare. Neurofibromas rarely involve the pleura. A review of the literarture reveals only a single reported case of isolated pleural neurofibroma. Herein the authors describe another case of isolated primary pleural neurofibroma. A 39-year-old nonsmoker woman presented to the emergency room with complaints of progressively worsening chest pain of one month duration. A computed tomography of the chest revealed a crescent shaped, pleural based mass suspicious for a neurogenic tumor such as an intercostal schwannoma. A PET-CT skull base to midthigh failed to reveal any other masses or abnormalities. A surgical excision of the mass was performed due to the patient's intractable pain. The resected specimen consisted of an ovoid fragment of soft tissue with pale yellow, smooth and glistening cut surface. Microscopic examination revealed the tumor to be composed of spindle cells with wavy nuclei arranged haphazardly in loose collagenous and pale myxoid stroma with rare interspersed mast cells. The spindle cells were diffusely positive for S100 protein and SOX-10, and focally positive for neurofilament. In the absence of any other masses in the patient and no pertinent history, a diagnosis of primary pleural neurofibroma was made. This case emphasizes the need to consider neurofibroma in any spindle cell neoplasm of the pleura irrespective of age or singularity. Hindawi 2019-11-24 /pmc/articles/PMC6906869/ /pubmed/31871813 http://dx.doi.org/10.1155/2019/6458302 Text en Copyright © 2019 Kritika Krishnamurthy et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Krishnamurthy, Kritika Alexis, John Basra, Pukhraz Medina, Ana Maria A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
title | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
title_full | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
title_fullStr | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
title_full_unstemmed | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
title_short | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
title_sort | case of isolated primary pleural neurofibroma in a 39-year-old woman |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906869/ https://www.ncbi.nlm.nih.gov/pubmed/31871813 http://dx.doi.org/10.1155/2019/6458302 |
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