Cargando…

Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells

Dysregulations of mitochondria with alterations in trafficking and morphology of these organelles have been related to Parkinson's disease (PD), a neurodegenerative disorder characterized by brain accumulation of Lewy bodies (LB), intraneuronal inclusions mainly composed of α-synuclein (α-syn)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faustini, Gaia, Marchesan, Elena, Zonta, Laura, Bono, Federica, Bottani, Emanuela, Longhena, Francesca, Ziviani, Elena, Valerio, Alessandra, Bellucci, Arianna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907050/ https://www.ncbi.nlm.nih.gov/pubmed/31871549 http://dx.doi.org/10.1155/2019/4246350

Ejemplares similares

Study of alpha-synuclein fibrillation: state of the art and expectations
por: Longhena, Francesca, et al.
Publicado: (2019)

Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
por: Brembati, Viviana, et al.
Publicado: (2023)

Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
por: Longhena, Francesca, et al.
Publicado: (2019)

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives
por: Bogale, Tizibt Ashine, et al.
Publicado: (2021)

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
por: Faustini, Gaia, et al.
Publicado: (2017)

Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease
por: Bellucci, Arianna, et al.
Publicado: (2020)

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease
por: Brembati, Viviana, et al.
Publicado: (2023)

The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy
por: Longhena, Francesca, et al.
Publicado: (2017)

Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson’s Disease: An In Situ Proximity Ligation Assay Study
por: Longhena, Francesca, et al.
Publicado: (2018)

Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice
por: Casiraghi, Andrea, et al.
Publicado: (2022)

Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype
por: Faustini, Gaia, et al.
Publicado: (2022)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
por: Zaltieri, Michela, et al.
Publicado: (2015)

Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
por: Filippini, Alice, et al.
Publicado: (2020)

Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction
por: Ponterio, Giulia, et al.
Publicado: (2022)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

Mitochondrial quality control beyond PINK1/Parkin
por: von Stockum, Sophia, et al.
Publicado: (2018)

The Association between α-Synuclein and α-Tubulin in Brain Synapses
por: Amadeo, Alida, et al.
Publicado: (2021)

Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates
por: Faustini, Gaia, et al.
Publicado: (2022)

NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice
por: Parrella, Edoardo, et al.
Publicado: (2019)

The Role of Rab Proteins in Parkinson’s Disease Synaptopathy
por: Bellucci, Arianna, et al.
Publicado: (2022)

Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
por: Risiglione, Pierpaolo, et al.
Publicado: (2021)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
por: Esteves, A. R., et al.
Publicado: (2011)

Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
por: Indrieri, Alessia, et al.
Publicado: (2020)

The relationship of alpha-synuclein to mitochondrial dynamics and quality control
por: Thorne, Naomi J., et al.
Publicado: (2022)

Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease
por: Bellucci, Arianna, et al.
Publicado: (2011)

Correction: Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease
por: Bellucci, Arianna, et al.
Publicado: (2012)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease
por: Masato, Anna, et al.
Publicado: (2023)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Subcellular localization of alpha-synuclein aggregates and their interaction with membranes
por: Miraglia, Fabiana, et al.
Publicado: (2018)

A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake
por: Cerqueira, Fernanda M., et al.
Publicado: (2020)

Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease
por: Gilmozzi, Valentina, et al.
Publicado: (2020)

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
por: Kieper, Nicole, et al.
Publicado: (2010)

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
por: Hu, Di, et al.
Publicado: (2019)

Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion
por: Tang, Qilin, et al.
Publicado: (2021)

Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
por: Rcom-H'cheo-Gauthier, Alexandre N., et al.
Publicado: (2016)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
por: Okita, Yuho, et al.
Publicado: (2017)

Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
por: Javanshiri, Keivan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_97r6drs82dcarddvqvi36rc0d9