Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region

BACKGROUND: Endometrial carcinoma (EC) accounts for 5.8% of all cancers in Saudi females. Although most ECs are sporadic, 2–5% tend to be familial, being associated with Lynch syndrome and Cowden syndrome. In this study, we attempted to uncover the frequency, spectrum and phenotype of germline mutat...

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Detalles Bibliográficos
Autores principales: Siraj, Abdul K., Parvathareddy, Sandeep Kumar, Bu, Rong, Iqbal, Kaleem, Siraj, Sarah, Masoodi, Tariq, Concepcion, Rica Micaela, Ghazwani, Laila Omar, AlBadawi, Ismail, Al-Dayel, Fouad, Al-Kuraya, Khawla S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907229/
https://www.ncbi.nlm.nih.gov/pubmed/31866764
http://dx.doi.org/10.1186/s12935-019-1058-9

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