Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity

BACKGROUND: Type V collagen (Col V) has the potential to become an autoantigen and has been associated with the pathogenesis of systemic sclerosis (SSc). We characterized serological, functional, and histopathological features of the skin and lung in a novel SSc murine model induced by Col V immuniz...

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Detalles Bibliográficos
Autores principales: Teodoro, Walcy Rosolia, de Jesus Queiroz, Zelita Aparecida, dos Santos, Lais Araujo, Catanozi, Sergio, dos Santos Filho, Antonio, Bueno, Cleonice, Vendramini, Margarete B. G., Fernezlian, Sandra de Morais, Eher, Esmeralda M., Sampaio-Barros, Percival D., Pasoto, Sandra Gofinet, Lopes, Fernanda Degobbi T. Q. S., Velosa, Ana Paula Pereira, Capelozzi, Vera Luiza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907238/
https://www.ncbi.nlm.nih.gov/pubmed/31829272
http://dx.doi.org/10.1186/s13075-019-2052-2

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