SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that participates in several age-related diseases. Using stable isotope labeling with amino acids (SILACs) and cultured cells, we identify 343 SASP proteins...

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Detalles Bibliográficos
Autores principales: Wiley, Christopher D., Liu, Su, Limbad, Chandani, Zawadzka, Anna M., Beck, Jennifer, Demaria, Marco, Artwood, Robert, Alimirah, Fatouma, Lopez-Dominguez, Jose-Alberto, Kuehnemann, Chisaka, Danielson, Steven R., Basisty, Natan, Kasler, Herbert G., Oron, Tal Ronnen, Desprez, Pierre-Yves, Mooney, Sean D., Gibson, Bradford W., Schilling, Birgit, Campisi, Judith, Kapahi, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907691/
https://www.ncbi.nlm.nih.gov/pubmed/31553904
http://dx.doi.org/10.1016/j.celrep.2019.08.049

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