Edetate Disodium-based Treatment in a Woman with Diabetes and Critical Limb Ischemia Scheduled for Lower Extremity Amputation

Historically, it is underappreciated that women undergoing amputation for critical limb ischemia (CLI) are older, more severely ill, and have a poorer prognosis than men. Epidemiological studies have shown an association between environmentally acquired vasculotoxic metals, coronary events, and peripheral artery disease. In this paper, we describe an elderly woman with CLI referred for primary amputation underwent edetate disodium-based treatment, known to reduce toxic metal burden, as a final option for limb salvage.