Straightjacket/α2δ3 deregulation is associated with cardiac conduction defects in myotonic dystrophy type 1

Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and...

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Detalles Bibliográficos
Autores principales: Auxerre-Plantié, Emilie, Nakamori, Masayuki, Renaud, Yoan, Huguet, Aline, Choquet, Caroline, Dondi, Cristiana, Miquerol, Lucile, Takahashi, Masanori P, Gourdon, Geneviève, Junion, Guillaume, Jagla, Teresa, Zmojdzian, Monika, Jagla, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908436/
https://www.ncbi.nlm.nih.gov/pubmed/31829940
http://dx.doi.org/10.7554/eLife.51114

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