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Quaking-induced conversion of prion protein on a thermal mixer accelerates detection in brains infected with transmissible spongiform encephalopathy agents

Detection of misfolded prion protein, PrP(TSE), in biological samples is important to develop antemortem tests for transmissible spongiform encephalopathies (TSEs). The real-time quaking-induced conversion (RT-QuIC) assay detects PrP(TSE) but requires dedicated equipment and relatively long incubati...

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Detalles Bibliográficos
Autores principales:	Kaelber, Nadine, Bett, Cyrus, Asher, David M., Gregori, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908438/ https://www.ncbi.nlm.nih.gov/pubmed/31830760 http://dx.doi.org/10.1371/journal.pone.0225904

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