The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy

Although mesothelioma is the consequence of a protracted immune response to asbestos fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches show less convincing results as compared to those seen in melanoma and non-small cell lung cancer. The immune suppressive microen...

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Autores principales: Chu, Gerard J., van Zandwijk, Nico, Rasko, John E. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908501/
https://www.ncbi.nlm.nih.gov/pubmed/31867277
http://dx.doi.org/10.3389/fonc.2019.01366
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author Chu, Gerard J.
van Zandwijk, Nico
Rasko, John E. J.
author_facet Chu, Gerard J.
van Zandwijk, Nico
Rasko, John E. J.
author_sort Chu, Gerard J.
collection PubMed
description Although mesothelioma is the consequence of a protracted immune response to asbestos fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches show less convincing results as compared to those seen in melanoma and non-small cell lung cancer. The immune suppressive microenvironment in mesothelioma is likely contributing to this therapy resistance. Therefore, it is important to explore the characteristics of the tumor microenvironment for explanations for this recalcitrant behavior. This review describes the stromal, cytokine, metabolic, and cellular milieu of mesothelioma, and attempts to make connection with the outcome of immunotherapy trials.
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spelling pubmed-69085012019-12-20 The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy Chu, Gerard J. van Zandwijk, Nico Rasko, John E. J. Front Oncol Oncology Although mesothelioma is the consequence of a protracted immune response to asbestos fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches show less convincing results as compared to those seen in melanoma and non-small cell lung cancer. The immune suppressive microenvironment in mesothelioma is likely contributing to this therapy resistance. Therefore, it is important to explore the characteristics of the tumor microenvironment for explanations for this recalcitrant behavior. This review describes the stromal, cytokine, metabolic, and cellular milieu of mesothelioma, and attempts to make connection with the outcome of immunotherapy trials. Frontiers Media S.A. 2019-12-06 /pmc/articles/PMC6908501/ /pubmed/31867277 http://dx.doi.org/10.3389/fonc.2019.01366 Text en Copyright © 2019 Chu, van Zandwijk and Rasko. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chu, Gerard J.
van Zandwijk, Nico
Rasko, John E. J.
The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy
title The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy
title_full The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy
title_fullStr The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy
title_full_unstemmed The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy
title_short The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy
title_sort immune microenvironment in mesothelioma: mechanisms of resistance to immunotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908501/
https://www.ncbi.nlm.nih.gov/pubmed/31867277
http://dx.doi.org/10.3389/fonc.2019.01366
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