A model of DNA damage response activation at stalled replication forks by SPRTN

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

Detalles Bibliográficos
Autores principales: Bruhn, Christopher, Foiani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908633/
https://www.ncbi.nlm.nih.gov/pubmed/31831745
http://dx.doi.org/10.1038/s41467-019-13610-7
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author Bruhn, Christopher
Foiani, Marco
author_facet Bruhn, Christopher
Foiani, Marco
author_sort Bruhn, Christopher
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description The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
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spelling pubmed-69086332019-12-16 A model of DNA damage response activation at stalled replication forks by SPRTN Bruhn, Christopher Foiani, Marco Nat Commun Comment The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks. Nature Publishing Group UK 2019-12-12 /pmc/articles/PMC6908633/ /pubmed/31831745 http://dx.doi.org/10.1038/s41467-019-13610-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Bruhn, Christopher
Foiani, Marco
A model of DNA damage response activation at stalled replication forks by SPRTN
title A model of DNA damage response activation at stalled replication forks by SPRTN
title_full A model of DNA damage response activation at stalled replication forks by SPRTN
title_fullStr A model of DNA damage response activation at stalled replication forks by SPRTN
title_full_unstemmed A model of DNA damage response activation at stalled replication forks by SPRTN
title_short A model of DNA damage response activation at stalled replication forks by SPRTN
title_sort model of dna damage response activation at stalled replication forks by sprtn
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908633/
https://www.ncbi.nlm.nih.gov/pubmed/31831745
http://dx.doi.org/10.1038/s41467-019-13610-7
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