The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population

Interleukin 17 (IL-17) plays pivotal role in the pathogenesis of psoriasis. In a previous study, we identified a locus in the IL17F gene that is associated with psoriasis, the IL17F rs763780 (His161Arg) T/C variant. The current study aimed to elucidate the association between this polymorphism and p...

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Autores principales: Choi, Byung Gon, Hong, Ji Youn, Hong, Joo Ran, Hur, Min Seok, Kim, Sung Min, Lee, Yang Won, Choe, Yong Beom, Ahn, Kyu Joong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908672/
https://www.ncbi.nlm.nih.gov/pubmed/31831764
http://dx.doi.org/10.1038/s41598-019-55062-5
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author Choi, Byung Gon
Hong, Ji Youn
Hong, Joo Ran
Hur, Min Seok
Kim, Sung Min
Lee, Yang Won
Choe, Yong Beom
Ahn, Kyu Joong
author_facet Choi, Byung Gon
Hong, Ji Youn
Hong, Joo Ran
Hur, Min Seok
Kim, Sung Min
Lee, Yang Won
Choe, Yong Beom
Ahn, Kyu Joong
author_sort Choi, Byung Gon
collection PubMed
description Interleukin 17 (IL-17) plays pivotal role in the pathogenesis of psoriasis. In a previous study, we identified a locus in the IL17F gene that is associated with psoriasis, the IL17F rs763780 (His161Arg) T/C variant. The current study aimed to elucidate the association between this polymorphism and psoriasis, and to determine its effect on serum levels of cytokine. A total of 116 psoriasis patients and 97 healthy volunteers were recruited. Genotyping analysis was performed using quantitative polymerase chain reaction, and serum levels of cytokine were measured using a multiplex immunoassay. The IL17F His161Arg polymorphism was significantly associated with psoriasis based on the genotype and allele analyses. Psoriasis patients harbouring the mutant allele had significantly increased serum levels of IL-17F. Our results suggest that this polymorphism is a potential risk locus for psoriasis and that it results in a direct increase in IL-17F production.
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spelling pubmed-69086722019-12-16 The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population Choi, Byung Gon Hong, Ji Youn Hong, Joo Ran Hur, Min Seok Kim, Sung Min Lee, Yang Won Choe, Yong Beom Ahn, Kyu Joong Sci Rep Article Interleukin 17 (IL-17) plays pivotal role in the pathogenesis of psoriasis. In a previous study, we identified a locus in the IL17F gene that is associated with psoriasis, the IL17F rs763780 (His161Arg) T/C variant. The current study aimed to elucidate the association between this polymorphism and psoriasis, and to determine its effect on serum levels of cytokine. A total of 116 psoriasis patients and 97 healthy volunteers were recruited. Genotyping analysis was performed using quantitative polymerase chain reaction, and serum levels of cytokine were measured using a multiplex immunoassay. The IL17F His161Arg polymorphism was significantly associated with psoriasis based on the genotype and allele analyses. Psoriasis patients harbouring the mutant allele had significantly increased serum levels of IL-17F. Our results suggest that this polymorphism is a potential risk locus for psoriasis and that it results in a direct increase in IL-17F production. Nature Publishing Group UK 2019-12-12 /pmc/articles/PMC6908672/ /pubmed/31831764 http://dx.doi.org/10.1038/s41598-019-55062-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Choi, Byung Gon
Hong, Ji Youn
Hong, Joo Ran
Hur, Min Seok
Kim, Sung Min
Lee, Yang Won
Choe, Yong Beom
Ahn, Kyu Joong
The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population
title The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population
title_full The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population
title_fullStr The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population
title_full_unstemmed The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population
title_short The IL17F His161Arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17F in an Asian population
title_sort il17f his161arg polymorphism, a potential risk locus for psoriasis, increases serum levels of interleukin-17f in an asian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908672/
https://www.ncbi.nlm.nih.gov/pubmed/31831764
http://dx.doi.org/10.1038/s41598-019-55062-5
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