Inline cartridge extraction for rapid brain tumor tissue identification by molecular profiling

The development of perspective diagnostic techniques in medicine requires efficient high-throughput biological sample analysis methods. Here, we present an inline cartridge extraction that facilitates the screening rate of mass spectrometry shotgun lipidomic analysis of tissue samples. We illustrate...

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Detalles Bibliográficos
Autores principales: Pekov, Stanislav I., Eliferov, Vasily A., Sorokin, Anatoly A., Shurkhay, Vsevolod A., Zhvansky, Evgeny S., Vorobyev, Alexander S., Potapov, Alexander A., Nikolaev, Eugene N., Popov, Igor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908710/
https://www.ncbi.nlm.nih.gov/pubmed/31831871
http://dx.doi.org/10.1038/s41598-019-55597-7
Descripción
Sumario:The development of perspective diagnostic techniques in medicine requires efficient high-throughput biological sample analysis methods. Here, we present an inline cartridge extraction that facilitates the screening rate of mass spectrometry shotgun lipidomic analysis of tissue samples. We illustrate the method by its application to tumor tissue identification in neurosurgery. In perspective, this high-performance method provides new possibilities for the investigation of cancer pathogenesis and metabolic disorders.

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