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Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release

Medical tubings in plasticized polyvinylchloride (PVC) are widely used for the infusion of medications but are known in some cases to cause content-container interactions (drug sorption and plasticizer release). The aim of this study was to assess interactions between drugs and five alternative mate...

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Autores principales: Tokhadze, N., Chennell, P., Bernard, L., Lambert, C., Pereira, B., Mailhot-Jensen, B., Sautou, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908714/
https://www.ncbi.nlm.nih.gov/pubmed/31831771
http://dx.doi.org/10.1038/s41598-019-55113-x
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author Tokhadze, N.
Chennell, P.
Bernard, L.
Lambert, C.
Pereira, B.
Mailhot-Jensen, B.
Sautou, V.
author_facet Tokhadze, N.
Chennell, P.
Bernard, L.
Lambert, C.
Pereira, B.
Mailhot-Jensen, B.
Sautou, V.
author_sort Tokhadze, N.
collection PubMed
description Medical tubings in plasticized polyvinylchloride (PVC) are widely used for the infusion of medications but are known in some cases to cause content-container interactions (drug sorption and plasticizer release). The aim of this study was to assess interactions between drugs and five alternative materials to a reference plasticized PVC intravenous (IV) infusion tubing: three were PVC coextruded with polyethylene (PE), polyurethane (PU) or a thermoplastic elastomer (Styrene-EthyleneButadiene-Styrene (SEBS)) and two were SEBS or thermoplastic olefin (TPO) monolayer tubings. Diazepam and insulin were chosen as respective reference of absorption and adsorption while paracetamol acted as a negative control. The concentration of each drug was quantified with liquid chromatography to evaluate a potential loss after a static contact condition and simulated infusion at 1 mL/h and 10 mL/h dynamic condition by an electric syringe pump. A characterization of each material’s surface was performed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR) and by measurement of surface zeta potential. Plasticizer release was quantified by gas chromatography coupled with mass spectrometry (GC-MS). For all tubings except PVC/PU, no loss of paracetamol was observed in any condition. Diazepam sorption appeared to be less important with PVC/PE, PVC/SEBS, SEBS and TPO tubings than with PVC, but was more important when using PVC/PU tubings. PVC tubings induced the least loss of insulin amongst all the studied materials. Surface analysis by ATR-FTIR highlighted the presence of a plasticizer (that could be attributed to Tris (2-Ethylhexyl) Trimellitate (TOTM)) in the coextruded SEBS layer of PVC/SEBS, which could have influenced drug sorption, probably as a consequence of a migration from the PVC layer. Coextruded PVC/SEBS and PVC/PE presented the lowest zeta potential of all studied materials with respective values of −39 mV and −36 mV and were related to the highest sorption of insulin while PVC/PU with the highest zeta potential (about −9 mV) presented the highest absorption of diazepam. Coextruded layered materials appeared to have a lower plasticizer release than PVC alone. As a conclusion, PVC/PE and thermoplastic elastomers alone or coextruded with PVC could be interesting alternatives to PVC tubings with regards to sorption phenomena and plasticizer release.
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spelling pubmed-69087142019-12-16 Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release Tokhadze, N. Chennell, P. Bernard, L. Lambert, C. Pereira, B. Mailhot-Jensen, B. Sautou, V. Sci Rep Article Medical tubings in plasticized polyvinylchloride (PVC) are widely used for the infusion of medications but are known in some cases to cause content-container interactions (drug sorption and plasticizer release). The aim of this study was to assess interactions between drugs and five alternative materials to a reference plasticized PVC intravenous (IV) infusion tubing: three were PVC coextruded with polyethylene (PE), polyurethane (PU) or a thermoplastic elastomer (Styrene-EthyleneButadiene-Styrene (SEBS)) and two were SEBS or thermoplastic olefin (TPO) monolayer tubings. Diazepam and insulin were chosen as respective reference of absorption and adsorption while paracetamol acted as a negative control. The concentration of each drug was quantified with liquid chromatography to evaluate a potential loss after a static contact condition and simulated infusion at 1 mL/h and 10 mL/h dynamic condition by an electric syringe pump. A characterization of each material’s surface was performed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR) and by measurement of surface zeta potential. Plasticizer release was quantified by gas chromatography coupled with mass spectrometry (GC-MS). For all tubings except PVC/PU, no loss of paracetamol was observed in any condition. Diazepam sorption appeared to be less important with PVC/PE, PVC/SEBS, SEBS and TPO tubings than with PVC, but was more important when using PVC/PU tubings. PVC tubings induced the least loss of insulin amongst all the studied materials. Surface analysis by ATR-FTIR highlighted the presence of a plasticizer (that could be attributed to Tris (2-Ethylhexyl) Trimellitate (TOTM)) in the coextruded SEBS layer of PVC/SEBS, which could have influenced drug sorption, probably as a consequence of a migration from the PVC layer. Coextruded PVC/SEBS and PVC/PE presented the lowest zeta potential of all studied materials with respective values of −39 mV and −36 mV and were related to the highest sorption of insulin while PVC/PU with the highest zeta potential (about −9 mV) presented the highest absorption of diazepam. Coextruded layered materials appeared to have a lower plasticizer release than PVC alone. As a conclusion, PVC/PE and thermoplastic elastomers alone or coextruded with PVC could be interesting alternatives to PVC tubings with regards to sorption phenomena and plasticizer release. Nature Publishing Group UK 2019-12-12 /pmc/articles/PMC6908714/ /pubmed/31831771 http://dx.doi.org/10.1038/s41598-019-55113-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tokhadze, N.
Chennell, P.
Bernard, L.
Lambert, C.
Pereira, B.
Mailhot-Jensen, B.
Sautou, V.
Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release
title Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release
title_full Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release
title_fullStr Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release
title_full_unstemmed Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release
title_short Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release
title_sort impact of alternative materials to plasticized pvc infusion tubings on drug sorption and plasticizer release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908714/
https://www.ncbi.nlm.nih.gov/pubmed/31831771
http://dx.doi.org/10.1038/s41598-019-55113-x
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