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Pathogenic memory plasma cells in autoimmunity
• Memory plasma cells are long-lived but require specialized niches for their survival. • Memory plasma cells are refractory to conventional immunosuppression. • Pathogenic memory plasma cells represent ‘roadblocks’ to response to conventional therapy. • Strategies for (selective) targeting of memor...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908965/ https://www.ncbi.nlm.nih.gov/pubmed/31675681 http://dx.doi.org/10.1016/j.coi.2019.09.005 |
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| author | Chang, Hyun-Dong Tokoyoda, Koji Hoyer, Bimba Alexander, Tobias Khodadadi, Laleh Mei, Henrik Dörner, Thomas Hiepe, Falk Burmester, Gerd-Rüdiger Radbruch, Andreas |
| author_facet | Chang, Hyun-Dong Tokoyoda, Koji Hoyer, Bimba Alexander, Tobias Khodadadi, Laleh Mei, Henrik Dörner, Thomas Hiepe, Falk Burmester, Gerd-Rüdiger Radbruch, Andreas |
| author_sort | Chang, Hyun-Dong |
| collection | PubMed |
| description | • Memory plasma cells are long-lived but require specialized niches for their survival. • Memory plasma cells are refractory to conventional immunosuppression. • Pathogenic memory plasma cells represent ‘roadblocks’ to response to conventional therapy. • Strategies for (selective) targeting of memory plasma cells are in preclinical and clinical tests. |
| format | Online Article Text |
| id | pubmed-6908965 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69089652019-12-23 Pathogenic memory plasma cells in autoimmunity Chang, Hyun-Dong Tokoyoda, Koji Hoyer, Bimba Alexander, Tobias Khodadadi, Laleh Mei, Henrik Dörner, Thomas Hiepe, Falk Burmester, Gerd-Rüdiger Radbruch, Andreas Curr Opin Immunol Article • Memory plasma cells are long-lived but require specialized niches for their survival. • Memory plasma cells are refractory to conventional immunosuppression. • Pathogenic memory plasma cells represent ‘roadblocks’ to response to conventional therapy. • Strategies for (selective) targeting of memory plasma cells are in preclinical and clinical tests. Elsevier 2019-12 /pmc/articles/PMC6908965/ /pubmed/31675681 http://dx.doi.org/10.1016/j.coi.2019.09.005 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Chang, Hyun-Dong Tokoyoda, Koji Hoyer, Bimba Alexander, Tobias Khodadadi, Laleh Mei, Henrik Dörner, Thomas Hiepe, Falk Burmester, Gerd-Rüdiger Radbruch, Andreas Pathogenic memory plasma cells in autoimmunity |
| title | Pathogenic memory plasma cells in autoimmunity |
| title_full | Pathogenic memory plasma cells in autoimmunity |
| title_fullStr | Pathogenic memory plasma cells in autoimmunity |
| title_full_unstemmed | Pathogenic memory plasma cells in autoimmunity |
| title_short | Pathogenic memory plasma cells in autoimmunity |
| title_sort | pathogenic memory plasma cells in autoimmunity |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908965/ https://www.ncbi.nlm.nih.gov/pubmed/31675681 http://dx.doi.org/10.1016/j.coi.2019.09.005 |
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