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Using Gene Editing to Establish a Safeguard System for Pluripotent Stem-Cell-Based Therapies

A major challenge in using human pluripotent stem cells (hPSCs) in therapy is the risk of teratoma formation due to contaminating undifferentiated stem cells. We used CRISPR-Cas9 for in-frame insertion of a suicide gene, iC9, into the endogenous SOX2 locus in human embryonic stem cell (ESC) line H1...

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Detalles Bibliográficos
Autores principales:	Wu, Youjun, Chang, Tammy, Long, Yan, Huang, He, Kandeel, Fouad, Yee, Jiing-Kuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909005/ https://www.ncbi.nlm.nih.gov/pubmed/31821946 http://dx.doi.org/10.1016/j.isci.2019.11.038

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