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Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues

BACKGROUND: Recent studies suggest that Posttraumatic Stress Disorder (PTSD) might be associated with dysfunctional reward circuitry. However, further research is needed to understand the key role of the reward system in PTSD symptomatology. METHODS: Twenty participants with PTSD and 21 Trauma-Expos...

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Autores principales: Boukezzi, Sarah, Baunez, Christelle, Rousseau, Pierre-François, Warrot, Delphine, Silva, Catarina, Guyon, Valérie, Zendjidjian, Xavier, Nicolas, Florian, Guedj, Eric, Nazarian, Bruno, Trousselard, Marion, Chaminade, Thierry, Khalfa, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909092/
https://www.ncbi.nlm.nih.gov/pubmed/31794925
http://dx.doi.org/10.1016/j.nicl.2019.102073
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author Boukezzi, Sarah
Baunez, Christelle
Rousseau, Pierre-François
Warrot, Delphine
Silva, Catarina
Guyon, Valérie
Zendjidjian, Xavier
Nicolas, Florian
Guedj, Eric
Nazarian, Bruno
Trousselard, Marion
Chaminade, Thierry
Khalfa, Stéphanie
author_facet Boukezzi, Sarah
Baunez, Christelle
Rousseau, Pierre-François
Warrot, Delphine
Silva, Catarina
Guyon, Valérie
Zendjidjian, Xavier
Nicolas, Florian
Guedj, Eric
Nazarian, Bruno
Trousselard, Marion
Chaminade, Thierry
Khalfa, Stéphanie
author_sort Boukezzi, Sarah
collection PubMed
description BACKGROUND: Recent studies suggest that Posttraumatic Stress Disorder (PTSD) might be associated with dysfunctional reward circuitry. However, further research is needed to understand the key role of the reward system in PTSD symptomatology. METHODS: Twenty participants with PTSD and 21 Trauma-Exposed matched Controls (TECs) completed the Monetary Incentive Delay (MID) task during an MRI session. Reaction times (RTs) and hit rates were recorded. Brain activity was investigated during the anticipation and the outcome of monetary gains and losses. RESULTS: During the anticipation of monetary loss, PTSD participants had higher RTs than TECs. However, the groups did not differ at the neurofunctional level. During successful avoidance of monetary loss, PTSD patients showed higher activation than TECs in the left caudate nucleus. During the anticipation of monetary gains, no differences in RTs were found between groups. PTSD patients had specific activations in the right amygdala, nucleus accumbens, putamen, and middle frontal gyrus (p < 0.05 family-wise error (FWE)-corrected), while TECs had specific activation in the anterior cingulate cortex. When obtaining monetary gains, PTSD patients had specific activation in the caudate nucleus, while TECs had specific activations in the right hypothalamus, subthalamic nucleus, and left inferior frontal gyrus. CONCLUSION: For the first time, functional brain activation during both the anticipation and the outcome of monetary rewards is reported altered in PTSD patients. These alterations might be associated with the complex symptomatology of PTSD.
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spelling pubmed-69090922019-12-23 Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues Boukezzi, Sarah Baunez, Christelle Rousseau, Pierre-François Warrot, Delphine Silva, Catarina Guyon, Valérie Zendjidjian, Xavier Nicolas, Florian Guedj, Eric Nazarian, Bruno Trousselard, Marion Chaminade, Thierry Khalfa, Stéphanie Neuroimage Clin Regular Article BACKGROUND: Recent studies suggest that Posttraumatic Stress Disorder (PTSD) might be associated with dysfunctional reward circuitry. However, further research is needed to understand the key role of the reward system in PTSD symptomatology. METHODS: Twenty participants with PTSD and 21 Trauma-Exposed matched Controls (TECs) completed the Monetary Incentive Delay (MID) task during an MRI session. Reaction times (RTs) and hit rates were recorded. Brain activity was investigated during the anticipation and the outcome of monetary gains and losses. RESULTS: During the anticipation of monetary loss, PTSD participants had higher RTs than TECs. However, the groups did not differ at the neurofunctional level. During successful avoidance of monetary loss, PTSD patients showed higher activation than TECs in the left caudate nucleus. During the anticipation of monetary gains, no differences in RTs were found between groups. PTSD patients had specific activations in the right amygdala, nucleus accumbens, putamen, and middle frontal gyrus (p < 0.05 family-wise error (FWE)-corrected), while TECs had specific activation in the anterior cingulate cortex. When obtaining monetary gains, PTSD patients had specific activation in the caudate nucleus, while TECs had specific activations in the right hypothalamus, subthalamic nucleus, and left inferior frontal gyrus. CONCLUSION: For the first time, functional brain activation during both the anticipation and the outcome of monetary rewards is reported altered in PTSD patients. These alterations might be associated with the complex symptomatology of PTSD. Elsevier 2019-11-05 /pmc/articles/PMC6909092/ /pubmed/31794925 http://dx.doi.org/10.1016/j.nicl.2019.102073 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Boukezzi, Sarah
Baunez, Christelle
Rousseau, Pierre-François
Warrot, Delphine
Silva, Catarina
Guyon, Valérie
Zendjidjian, Xavier
Nicolas, Florian
Guedj, Eric
Nazarian, Bruno
Trousselard, Marion
Chaminade, Thierry
Khalfa, Stéphanie
Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues
title Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues
title_full Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues
title_fullStr Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues
title_full_unstemmed Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues
title_short Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues
title_sort posttraumatic stress disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909092/
https://www.ncbi.nlm.nih.gov/pubmed/31794925
http://dx.doi.org/10.1016/j.nicl.2019.102073
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