Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles

BACKGROUND: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection. METHODS: The cross-reactivity between three strains from the last outbreak of N. meningitidi...

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Detalles Bibliográficos
Autores principales: Trzewikoswki de Lima, Gabriela, Portilho, Amanda Izeli, De Gaspari, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909266/
https://www.ncbi.nlm.nih.gov/pubmed/31853514
http://dx.doi.org/10.1177/2515135519894825
Descripción
Sumario:BACKGROUND: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection. METHODS: The cross-reactivity between three strains from the last outbreak of N. meningitidis in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays. RESULTS: Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated. CONCLUSIONS: We observed that immunization with N. meningitidis B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains.

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