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Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles

BACKGROUND: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection. METHODS: The cross-reactivity between three strains from the last outbreak of N. meningitidi...

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Autores principales: Trzewikoswki de Lima, Gabriela, Portilho, Amanda Izeli, De Gaspari, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909266/
https://www.ncbi.nlm.nih.gov/pubmed/31853514
http://dx.doi.org/10.1177/2515135519894825
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author Trzewikoswki de Lima, Gabriela
Portilho, Amanda Izeli
De Gaspari, Elizabeth
author_facet Trzewikoswki de Lima, Gabriela
Portilho, Amanda Izeli
De Gaspari, Elizabeth
author_sort Trzewikoswki de Lima, Gabriela
collection PubMed
description BACKGROUND: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection. METHODS: The cross-reactivity between three strains from the last outbreak of N. meningitidis in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays. RESULTS: Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated. CONCLUSIONS: We observed that immunization with N. meningitidis B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains.
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spelling pubmed-69092662019-12-18 Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles Trzewikoswki de Lima, Gabriela Portilho, Amanda Izeli De Gaspari, Elizabeth Ther Adv Vaccines Immunother Original Research BACKGROUND: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection. METHODS: The cross-reactivity between three strains from the last outbreak of N. meningitidis in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays. RESULTS: Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated. CONCLUSIONS: We observed that immunization with N. meningitidis B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains. SAGE Publications 2019-12-11 /pmc/articles/PMC6909266/ /pubmed/31853514 http://dx.doi.org/10.1177/2515135519894825 Text en © The Author(s), 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Trzewikoswki de Lima, Gabriela
Portilho, Amanda Izeli
De Gaspari, Elizabeth
Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles
title Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles
title_full Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles
title_fullStr Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles
title_full_unstemmed Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles
title_short Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles
title_sort cross-reactivity with brazilian strains of neisseria meningitidis b after immunization with outer membrane vesicles
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909266/
https://www.ncbi.nlm.nih.gov/pubmed/31853514
http://dx.doi.org/10.1177/2515135519894825
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