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How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease

OBJECTIVE: Freezing of gait (FoG) is a debilitating problem in patients with PD. The multifactorial pathogenesis of FoG remains poorly understood. We aimed to find which factors are most strongly associated with the occurrence of FoG. METHODS: Three hundred five PD patients were enrolled and subdivi...

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Autores principales: Ortelli, Paola, Ferrazzoli, Davide, Cian, Veronica, Zarucchi, Marianna, Palamara, Grazia, Giobbia, Alessandro, Frazzitta, Giuseppe, Maestri, Roberto, Canesi, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909398/
https://www.ncbi.nlm.nih.gov/pubmed/31866812
http://dx.doi.org/10.3389/fnins.2019.01302
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author Ortelli, Paola
Ferrazzoli, Davide
Cian, Veronica
Zarucchi, Marianna
Palamara, Grazia
Giobbia, Alessandro
Frazzitta, Giuseppe
Maestri, Roberto
Canesi, Margherita
author_facet Ortelli, Paola
Ferrazzoli, Davide
Cian, Veronica
Zarucchi, Marianna
Palamara, Grazia
Giobbia, Alessandro
Frazzitta, Giuseppe
Maestri, Roberto
Canesi, Margherita
author_sort Ortelli, Paola
collection PubMed
description OBJECTIVE: Freezing of gait (FoG) is a debilitating problem in patients with PD. The multifactorial pathogenesis of FoG remains poorly understood. We aimed to find which factors are most strongly associated with the occurrence of FoG. METHODS: Three hundred five PD patients were enrolled and subdivided according to the presence (FoG +, n = 128) or absence (FoG-, n = 177) of FoG. Several clinical, functional, and neuropsychological data were collected and compared between groups. The association between the probability of presence of FoG and possible explanatory variables was assessed by logistic regression analysis. RESULTS: FoG + patients were younger at the diagnosis (p = 0.04), and their mean daily dose of dopaminergic drugs (p < 0.0001) was higher in comparison with FoG- patients. FoG + patients get worse in Frontal Assessment Battery (p = 0.005), had higher scores in Apathy Evaluation Scale (p = 0.03), and were much more impaired on Wisconsin Card Sorting Test (WCST) (p = 0.018), Trail Making Test A (p = 0.0013), and Ray Auditory Verbal Learning Test (p = 0.012). Levodopa equivalent dose, age (direct), age at disease onset (inverse), and WCST were significant predictors of FoG (p = 0.01, p = 0.0025, p = 0.0016, and p = 0.029, respectively). CONCLUSION: FoG + patients show more deficits in executive functions and in motivation. The main explanatory variables of FoG occurrence are levodopa equivalent dose, age, age at disease onset, and WCST. These data suggest that a specific involvement of frontal cortical circuits in PD is responsible for certain cognitive–behavioral alterations related to the occurrence of FoG.
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spelling pubmed-69093982019-12-20 How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease Ortelli, Paola Ferrazzoli, Davide Cian, Veronica Zarucchi, Marianna Palamara, Grazia Giobbia, Alessandro Frazzitta, Giuseppe Maestri, Roberto Canesi, Margherita Front Neurosci Neuroscience OBJECTIVE: Freezing of gait (FoG) is a debilitating problem in patients with PD. The multifactorial pathogenesis of FoG remains poorly understood. We aimed to find which factors are most strongly associated with the occurrence of FoG. METHODS: Three hundred five PD patients were enrolled and subdivided according to the presence (FoG +, n = 128) or absence (FoG-, n = 177) of FoG. Several clinical, functional, and neuropsychological data were collected and compared between groups. The association between the probability of presence of FoG and possible explanatory variables was assessed by logistic regression analysis. RESULTS: FoG + patients were younger at the diagnosis (p = 0.04), and their mean daily dose of dopaminergic drugs (p < 0.0001) was higher in comparison with FoG- patients. FoG + patients get worse in Frontal Assessment Battery (p = 0.005), had higher scores in Apathy Evaluation Scale (p = 0.03), and were much more impaired on Wisconsin Card Sorting Test (WCST) (p = 0.018), Trail Making Test A (p = 0.0013), and Ray Auditory Verbal Learning Test (p = 0.012). Levodopa equivalent dose, age (direct), age at disease onset (inverse), and WCST were significant predictors of FoG (p = 0.01, p = 0.0025, p = 0.0016, and p = 0.029, respectively). CONCLUSION: FoG + patients show more deficits in executive functions and in motivation. The main explanatory variables of FoG occurrence are levodopa equivalent dose, age, age at disease onset, and WCST. These data suggest that a specific involvement of frontal cortical circuits in PD is responsible for certain cognitive–behavioral alterations related to the occurrence of FoG. Frontiers Media S.A. 2019-12-06 /pmc/articles/PMC6909398/ /pubmed/31866812 http://dx.doi.org/10.3389/fnins.2019.01302 Text en Copyright © 2019 Ortelli, Ferrazzoli, Cian, Zarucchi, Palamara, Giobbia, Frazzitta, Maestri and Canesi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ortelli, Paola
Ferrazzoli, Davide
Cian, Veronica
Zarucchi, Marianna
Palamara, Grazia
Giobbia, Alessandro
Frazzitta, Giuseppe
Maestri, Roberto
Canesi, Margherita
How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease
title How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease
title_full How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease
title_fullStr How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease
title_full_unstemmed How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease
title_short How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease
title_sort how cognition and motivation “freeze” the motor behavior in parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909398/
https://www.ncbi.nlm.nih.gov/pubmed/31866812
http://dx.doi.org/10.3389/fnins.2019.01302
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