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Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University

BACKGROUND: Radical radiotherapy is the standard treatment for patients with locally advanced cervix uteri carcinoma (FIGO stage IB2–IVA). Worldwide, incidence and mortality rates vary among regions because of differences in lifestyles and treatment standards. Herein, we evaluated the outcomes of ra...

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Autores principales: Serarslan, Alparslan, Gursel, Bilge, Meydan, Deniz, Ozbek Okumus, Nilgun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909517/
https://www.ncbi.nlm.nih.gov/pubmed/31830953
http://dx.doi.org/10.1186/s12885-019-6402-x
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author Serarslan, Alparslan
Gursel, Bilge
Meydan, Deniz
Ozbek Okumus, Nilgun
author_facet Serarslan, Alparslan
Gursel, Bilge
Meydan, Deniz
Ozbek Okumus, Nilgun
author_sort Serarslan, Alparslan
collection PubMed
description BACKGROUND: Radical radiotherapy is the standard treatment for patients with locally advanced cervix uteri carcinoma (FIGO stage IB2–IVA). Worldwide, incidence and mortality rates vary among regions because of differences in lifestyles and treatment standards. Herein, we evaluated the outcomes of radical radiotherapy in patients with locally advanced cervix uteri carcinoma from the middle Black Sea region of Turkey. METHODS: We retrospectively reviewed the records of 64 consecutive patients with locally advanced cervix uteri carcinoma who were treated from January 2013 to 2016 in our radiation oncology department. All patients staging and radiotherapy planning were performed with modern imaging techniques including magnetic resonance imaging and positron-emission-tomography/computed tomography before radical radiotherapy. Thereafter, all of them were treated with external beam radiotherapy and concurrent cis-platinum-based chemotherapy followed by three-dimensional intra-cavitary high-dose-rate brachytherapy. RESULTS: The median age at diagnosis was 54.5 years. The median follow-up period was 21 months. Acute grade 3 toxicity was detected in 3.1% of patients. Late toxicity was not detected in any patient. The 1- and 3-year progression-free survival rates were 83.6 and 67.5%, respectively. The 1- and 3-year overall survival rates were 95.7 and 76.9%, respectively. The most important prognostic factor was the FIGO stage. Distant metastasis was the most common cause of death in patients with locally advanced cervix uteri carcinoma despite radical radiotherapy. CONCLUSIONS: In patients with locally-advanced cervix uteri carcinoma from the middle Black Sea region of our developing country, acceptable toxicity and survival rates are achieved similar to the recent literature from developed countries with using of modern staging, planning and radical radiotherapy techniques. However, recurrence was mostly in the form of distant metastases and further investigations on systemic therapies are required.
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spelling pubmed-69095172019-12-19 Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University Serarslan, Alparslan Gursel, Bilge Meydan, Deniz Ozbek Okumus, Nilgun BMC Cancer Research Article BACKGROUND: Radical radiotherapy is the standard treatment for patients with locally advanced cervix uteri carcinoma (FIGO stage IB2–IVA). Worldwide, incidence and mortality rates vary among regions because of differences in lifestyles and treatment standards. Herein, we evaluated the outcomes of radical radiotherapy in patients with locally advanced cervix uteri carcinoma from the middle Black Sea region of Turkey. METHODS: We retrospectively reviewed the records of 64 consecutive patients with locally advanced cervix uteri carcinoma who were treated from January 2013 to 2016 in our radiation oncology department. All patients staging and radiotherapy planning were performed with modern imaging techniques including magnetic resonance imaging and positron-emission-tomography/computed tomography before radical radiotherapy. Thereafter, all of them were treated with external beam radiotherapy and concurrent cis-platinum-based chemotherapy followed by three-dimensional intra-cavitary high-dose-rate brachytherapy. RESULTS: The median age at diagnosis was 54.5 years. The median follow-up period was 21 months. Acute grade 3 toxicity was detected in 3.1% of patients. Late toxicity was not detected in any patient. The 1- and 3-year progression-free survival rates were 83.6 and 67.5%, respectively. The 1- and 3-year overall survival rates were 95.7 and 76.9%, respectively. The most important prognostic factor was the FIGO stage. Distant metastasis was the most common cause of death in patients with locally advanced cervix uteri carcinoma despite radical radiotherapy. CONCLUSIONS: In patients with locally-advanced cervix uteri carcinoma from the middle Black Sea region of our developing country, acceptable toxicity and survival rates are achieved similar to the recent literature from developed countries with using of modern staging, planning and radical radiotherapy techniques. However, recurrence was mostly in the form of distant metastases and further investigations on systemic therapies are required. BioMed Central 2019-12-12 /pmc/articles/PMC6909517/ /pubmed/31830953 http://dx.doi.org/10.1186/s12885-019-6402-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Serarslan, Alparslan
Gursel, Bilge
Meydan, Deniz
Ozbek Okumus, Nilgun
Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University
title Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University
title_full Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University
title_fullStr Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University
title_full_unstemmed Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University
title_short Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University
title_sort radical radiotherapy in patients with cervix uteri carcinoma: experience of ondokuz mayis university
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909517/
https://www.ncbi.nlm.nih.gov/pubmed/31830953
http://dx.doi.org/10.1186/s12885-019-6402-x
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