EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease

BACKGROUND: EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer’s disease (AD), characterized by synapse dysfunction and loss, and the progressive loss of memory and other cognitive function...

Descripción completa

Detalles Bibliográficos
Autores principales: Poppe, Lindsay, Rué, Laura, Timmers, Mieke, Lenaerts, Annette, Storm, Annet, Callaerts-Vegh, Zsuzsanna, Courtand, Gilles, de Boer, Antina, Smolders, Silke, Van Damme, Philip, Van Den Bosch, Ludo, D’Hooge, Rudi, De Strooper, Bart, Robberecht, Wim, Lemmens, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909519/
https://www.ncbi.nlm.nih.gov/pubmed/31831046
http://dx.doi.org/10.1186/s13195-019-0554-4

Ejemplares similares

Ejemplares similares