Cargando…

FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake

BACKGROUND: Tacrolimus (FK506)-induced diabetes mellitus is one of the most important factors of post-transplant diabetes mellitus (PTDM). However, the detailed mechanisms underlying PTDM are still unclear. Farnesoid X receptor (FXR) regulates glycolipid metabolism. The objective of this study was t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ling, Zhao, Huijia, Chen, Binyao, Fan, Zhipeng, Li, Ning, Yue, Jiang, Ye, Qifa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909577/ https://www.ncbi.nlm.nih.gov/pubmed/31836014 http://dx.doi.org/10.1186/s12967-019-02170-5

Ejemplares similares

Noninvasive Identification of Immune-Related Biomarkers in Hepatocellular Carcinoma
por: Li, Ling, et al.
Publicado: (2019)

New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review
por: Nandula, Savitri Aninditha, et al.
Publicado: (2022)

Fast Tacrolimus Metabolism Does Not Promote Post-Transplant Diabetes Mellitus after Kidney Transplantation
por: Jehn, Ulrich, et al.
Publicado: (2022)

H(+)-ATPase blockade reduced renal gluconeogenesis and plasma glucose in a diabetic rat model
por: Tojo, Akihiro, et al.
Publicado: (2018)

Role of FXR in Renal Physiology and Kidney Diseases
por: Guo, Yanlin, et al.
Publicado: (2023)

Conversion from Tacrolimus to Cyclosporine A Improves Glucose Tolerance in HCV-Positive Renal Transplant Recipients
por: Handisurya, Ammon, et al.
Publicado: (2016)

Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression
por: Baron, Pedro W., et al.
Publicado: (2017)

Ginseng Pectin WGPA Alleviates Exercise-Induced Fatigue by Enhancing Gluconeogenesis
por: Jiao, Yang, et al.
Publicado: (2022)

Tacrolimus-induced Epidermoid Cysts in the Renal Transplant Patient
por: Tiwari, Vaibhav, et al.
Publicado: (2021)

Effects of Wuzhi Capsules on Blood Concentration of Tacrolimus in Renal Transplant Recipients
por: Yan, Lin, et al.
Publicado: (2019)

Post renal transplant pure red cell aplasia—is tacrolimus a culprit?
por: Patil, Malagouda R., et al.
Publicado: (2016)

Genistein Alleviates High-Fat Diet-Induced Obesity by Inhibiting the Process of Gluconeogenesis in Mice
por: Gan, Mailin, et al.
Publicado: (2022)

Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice
por: Qiu, Yuxiang, et al.
Publicado: (2023)

Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo
por: Ferjani, Ali, et al.
Publicado: (2018)

Control of Blood Glucose in the Absence of Hepatic Glucose Production During Prolonged Fasting in Mice: Induction of Renal and Intestinal Gluconeogenesis by Glucagon
por: Mutel, Elodie, et al.
Publicado: (2011)

FXR Signaling-Mediated Bile Acid Metabolism Is Critical for Alleviation of Cholesterol Gallstones by Lactobacillus Strains
por: Ye, Xin, et al.
Publicado: (2022)

Epidermal Cysts in a Tacrolimus Treated Renal Transplant Recipient
por: Ahn, In Su, et al.
Publicado: (2011)

Massive pleural effusion in a renal transplant recipient on tacrolimus
por: Nayagam, L. S., et al.
Publicado: (2014)

Individualized Dosage of Tacrolimus for Renal Transplantation Patients Based on Pharmacometabonomics
por: He, Xiaoying, et al.
Publicado: (2022)

Metformin alleviates irradiation-induced intestinal injury by activation of FXR in intestinal epithelia
por: Yang, Jing-Yu, et al.
Publicado: (2022)

Post-transplant Diabetes Mellitus in Kidney Transplant Recipients in Sudan: A Comparison Between Tacrolimus and Cyclosporine-Based Immunosuppression
por: Yousif, Elamein, et al.
Publicado: (2022)

Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic Gluconeogenesis
por: Xia, Xuan, et al.
Publicado: (2011)

Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation
por: Shu, Xiangbing, et al.
Publicado: (2021)

G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis
por: Bielczyk-Maczynska, Ewa, et al.
Publicado: (2022)

Renal gluconeogenesis in insulin resistance: A culprit for hyperglycemia in diabetes
por: Sharma, Rajni, et al.
Publicado: (2021)

O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing
por: Benhamed, Fadila, et al.
Publicado: (2015)

The Role of the Nuclear Receptor FXR in Arsenic-Induced Glucose Intolerance in Mice
por: Yang, Yifei, et al.
Publicado: (2023)

Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity
por: Liu, Changhui, et al.
Publicado: (2022)

Conversion from Standard-Release Tacrolimus to MeltDose(®) Tacrolimus (LCPT) Improves Renal Function after Liver Transplantation
por: von Einsiedel, Johannes, et al.
Publicado: (2020)

Immunomodulation in stable renal transplant recipients with concomitant tacrolimus and sirolimus therapy
por: Khanna, Ashwani, et al.
Publicado: (2002)

The Tacrolimus Metabolism Rate Influences Renal Function after Kidney Transplantation
por: Thölking, Gerold, et al.
Publicado: (2014)

Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
por: Guerra, Augusto Afonso, et al.
Publicado: (2015)

Application of Machine-Learning Models to Predict Tacrolimus Stable Dose in Renal Transplant Recipients
por: Tang, Jie, et al.
Publicado: (2017)

Cerebral Gluconeogenesis and Diseases
por: Yip, James, et al.
Publicado: (2017)

Fatty acids-stress attenuates gluconeogenesis induction and glucose production in primary hepatocytes
por: Budick-Harmelin, Noga, et al.
Publicado: (2012)

Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis
por: Velmurugan, Ganesan, et al.
Publicado: (2017)

Author Correction: Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo
por: Ferjani, Ali, et al.
Publicado: (2019)

Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis
por: Alves, Anaïs, et al.
Publicado: (2022)

Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress
por: Zhong, Yadi, et al.
Publicado: (2022)

Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
por: Tojo, Akihiro, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_m0splr9jiqr5egkj17nfe5vung