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Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients
Renal osteodystrophy (ROD) represents bone disorders related to chronic kidney disease (CKD) and several bone biomarkers are used clinically to predict ROD in CKD and hemodialysis (HD) patients. Serum albumin associates with inflammation other than nutritional status in these patients. Chronic infla...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909808/ https://www.ncbi.nlm.nih.gov/pubmed/31839746 http://dx.doi.org/10.7150/ijms.39158 |
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author | Zheng, Cai Mei Wu, Chia Chao Lu, Chien Lin Hou, Yi Chou Wu, Mai Szu Hsu, Yung Ho Chen, Remy Chang, Tian Jong Shyu, Jia Fwu Lin, Yuh Feng Lu, Kuo Cheng |
author_facet | Zheng, Cai Mei Wu, Chia Chao Lu, Chien Lin Hou, Yi Chou Wu, Mai Szu Hsu, Yung Ho Chen, Remy Chang, Tian Jong Shyu, Jia Fwu Lin, Yuh Feng Lu, Kuo Cheng |
author_sort | Zheng, Cai Mei |
collection | PubMed |
description | Renal osteodystrophy (ROD) represents bone disorders related to chronic kidney disease (CKD) and several bone biomarkers are used clinically to predict ROD in CKD and hemodialysis (HD) patients. Serum albumin associates with inflammation other than nutritional status in these patients. Chronic inflammation is proved to relate with bone loss, however, the influence of hypoalbuminemia on bone biomarkers is still unclear. In this study, we evaluated the pattern of bone biomarker changes and further studied the influence of hypoalbuminemia on these biomarkers. A total of 300 maintenance HD patients were evaluated and 223 HD patients were included in the study. The patients were grouped according to serum parathyroid hormone (PTH) levels (PTH ≤150 pg/mL, PTH 150-300 pg/mL, PTH 300-600 pg/mL and PTH >600 pg/mL). Bone biomarkers and inflammatory markers were measured and their relation with PTH levels was determined. Significantly increased interleukin-6 (IL-6) and lower albumin levels were noted among PTH>600 pg/mL group. Bone turnover markers were significantly higher in PTH >600 pg/mL group (p< 0.05). Hypoalbuminemia significantly increased the fibroblast growth factor-23 (FGF-23) and procollagen type 1N-terminal propeptide (P1NP) in PTH ≤150 pg/mL, PTH 150-300 pg/mL, PTH 300-600 pg/mL groups, whereas no such relation was noted among PTH> 600 ng/dL group. In conclusion, hypoalbuminemia represents a chronic inflammation which differently relates to bone turnover markers according to serum PTH levels in SHPT patients. Thus, serum albumin measurement should be considered in determining bone disorders among these patients. |
format | Online Article Text |
id | pubmed-6909808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-69098082019-12-14 Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients Zheng, Cai Mei Wu, Chia Chao Lu, Chien Lin Hou, Yi Chou Wu, Mai Szu Hsu, Yung Ho Chen, Remy Chang, Tian Jong Shyu, Jia Fwu Lin, Yuh Feng Lu, Kuo Cheng Int J Med Sci Research Paper Renal osteodystrophy (ROD) represents bone disorders related to chronic kidney disease (CKD) and several bone biomarkers are used clinically to predict ROD in CKD and hemodialysis (HD) patients. Serum albumin associates with inflammation other than nutritional status in these patients. Chronic inflammation is proved to relate with bone loss, however, the influence of hypoalbuminemia on bone biomarkers is still unclear. In this study, we evaluated the pattern of bone biomarker changes and further studied the influence of hypoalbuminemia on these biomarkers. A total of 300 maintenance HD patients were evaluated and 223 HD patients were included in the study. The patients were grouped according to serum parathyroid hormone (PTH) levels (PTH ≤150 pg/mL, PTH 150-300 pg/mL, PTH 300-600 pg/mL and PTH >600 pg/mL). Bone biomarkers and inflammatory markers were measured and their relation with PTH levels was determined. Significantly increased interleukin-6 (IL-6) and lower albumin levels were noted among PTH>600 pg/mL group. Bone turnover markers were significantly higher in PTH >600 pg/mL group (p< 0.05). Hypoalbuminemia significantly increased the fibroblast growth factor-23 (FGF-23) and procollagen type 1N-terminal propeptide (P1NP) in PTH ≤150 pg/mL, PTH 150-300 pg/mL, PTH 300-600 pg/mL groups, whereas no such relation was noted among PTH> 600 ng/dL group. In conclusion, hypoalbuminemia represents a chronic inflammation which differently relates to bone turnover markers according to serum PTH levels in SHPT patients. Thus, serum albumin measurement should be considered in determining bone disorders among these patients. Ivyspring International Publisher 2019-10-21 /pmc/articles/PMC6909808/ /pubmed/31839746 http://dx.doi.org/10.7150/ijms.39158 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Zheng, Cai Mei Wu, Chia Chao Lu, Chien Lin Hou, Yi Chou Wu, Mai Szu Hsu, Yung Ho Chen, Remy Chang, Tian Jong Shyu, Jia Fwu Lin, Yuh Feng Lu, Kuo Cheng Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients |
title | Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients |
title_full | Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients |
title_fullStr | Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients |
title_full_unstemmed | Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients |
title_short | Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients |
title_sort | hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909808/ https://www.ncbi.nlm.nih.gov/pubmed/31839746 http://dx.doi.org/10.7150/ijms.39158 |
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