Development of Small-Molecule Inhibitors Against Zika Virus Infection

In recent years, the outbreak of infectious disease caused by Zika virus (ZIKV) has posed a major threat to global public health, calling for the development of therapeutics to treat ZIKV disease. Here, we have described the different stages of the ZIKV life cycle and summarized the latest progress...

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Detalles Bibliográficos
Autores principales: Wang, Lili, Liang, Ruiying, Gao, Yaning, Li, Yanbai, Deng, Xiaoqian, Xiang, Rong, Zhang, Yina, Ying, Tianlei, Jiang, Shibo, Yu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909824/
https://www.ncbi.nlm.nih.gov/pubmed/31866959
http://dx.doi.org/10.3389/fmicb.2019.02725
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author Wang, Lili
Liang, Ruiying
Gao, Yaning
Li, Yanbai
Deng, Xiaoqian
Xiang, Rong
Zhang, Yina
Ying, Tianlei
Jiang, Shibo
Yu, Fei
author_facet Wang, Lili
Liang, Ruiying
Gao, Yaning
Li, Yanbai
Deng, Xiaoqian
Xiang, Rong
Zhang, Yina
Ying, Tianlei
Jiang, Shibo
Yu, Fei
author_sort Wang, Lili
collection PubMed
description In recent years, the outbreak of infectious disease caused by Zika virus (ZIKV) has posed a major threat to global public health, calling for the development of therapeutics to treat ZIKV disease. Here, we have described the different stages of the ZIKV life cycle and summarized the latest progress in the development of small-molecule inhibitors against ZIKV infection. We have also discussed some general strategies for the discovery of small-molecule ZIKV inhibitors.
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spelling pubmed-69098242019-12-20 Development of Small-Molecule Inhibitors Against Zika Virus Infection Wang, Lili Liang, Ruiying Gao, Yaning Li, Yanbai Deng, Xiaoqian Xiang, Rong Zhang, Yina Ying, Tianlei Jiang, Shibo Yu, Fei Front Microbiol Microbiology In recent years, the outbreak of infectious disease caused by Zika virus (ZIKV) has posed a major threat to global public health, calling for the development of therapeutics to treat ZIKV disease. Here, we have described the different stages of the ZIKV life cycle and summarized the latest progress in the development of small-molecule inhibitors against ZIKV infection. We have also discussed some general strategies for the discovery of small-molecule ZIKV inhibitors. Frontiers Media S.A. 2019-12-06 /pmc/articles/PMC6909824/ /pubmed/31866959 http://dx.doi.org/10.3389/fmicb.2019.02725 Text en Copyright © 2019 Wang, Liang, Gao, Li, Deng, Xiang, Zhang, Ying, Jiang and Yu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Lili
Liang, Ruiying
Gao, Yaning
Li, Yanbai
Deng, Xiaoqian
Xiang, Rong
Zhang, Yina
Ying, Tianlei
Jiang, Shibo
Yu, Fei
Development of Small-Molecule Inhibitors Against Zika Virus Infection
title Development of Small-Molecule Inhibitors Against Zika Virus Infection
title_full Development of Small-Molecule Inhibitors Against Zika Virus Infection
title_fullStr Development of Small-Molecule Inhibitors Against Zika Virus Infection
title_full_unstemmed Development of Small-Molecule Inhibitors Against Zika Virus Infection
title_short Development of Small-Molecule Inhibitors Against Zika Virus Infection
title_sort development of small-molecule inhibitors against zika virus infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909824/
https://www.ncbi.nlm.nih.gov/pubmed/31866959
http://dx.doi.org/10.3389/fmicb.2019.02725
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