The effects of long non-coding ribonucleic acids on various cellular components in rheumatoid arthritis

RA is a chronic, autoimmune-mediated inflammatory pathology. Long non-coding RNAs (lncRNAs) are a novel group of non-coding RNAs with a length of >200 nucleotides. There are reports emerging that suggest that lncRNAs participate in establishing and sustaining autoimmune diseases, including RA. In...

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Detalles Bibliográficos
Autores principales: Fang, Yilong, Tu, Jiajie, Han, Dafei, Guo, Yawei, Hong, Wenming, Wei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909907/
https://www.ncbi.nlm.nih.gov/pubmed/31605483
http://dx.doi.org/10.1093/rheumatology/kez472
Descripción
Sumario:RA is a chronic, autoimmune-mediated inflammatory pathology. Long non-coding RNAs (lncRNAs) are a novel group of non-coding RNAs with a length of >200 nucleotides. There are reports emerging that suggest that lncRNAs participate in establishing and sustaining autoimmune diseases, including RA. In this review article, we highlight the functions of lncRNAs in different cell types in RA. Our review indicates that lncRNAs affect various cellular components and are novel candidates that could constitute promising targets for the diagnosis and treatment of RA.

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