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Umbilical cord blood quality and quantity: Collection up to transplantation

Umbilical cord blood (UCB) is an attractive source of hematopoietic stem cells for transplantation in some blood disorders. One of the major factors that influence on transplantation fate is cord blood (CB) cell count, in addition to human leukocyte antigen similarity and CD34+ cell number. Here, we...

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Autores principales: Mousavi, Seyed Hadi, Zarrabi, Morteza, Abroun, Saeid, Ahmadipanah, Mona, Abbaspanah, Bahareh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910041/
https://www.ncbi.nlm.nih.gov/pubmed/31896912
http://dx.doi.org/10.4103/ajts.AJTS_124_18
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author Mousavi, Seyed Hadi
Zarrabi, Morteza
Abroun, Saeid
Ahmadipanah, Mona
Abbaspanah, Bahareh
author_facet Mousavi, Seyed Hadi
Zarrabi, Morteza
Abroun, Saeid
Ahmadipanah, Mona
Abbaspanah, Bahareh
author_sort Mousavi, Seyed Hadi
collection PubMed
description Umbilical cord blood (UCB) is an attractive source of hematopoietic stem cells for transplantation in some blood disorders. One of the major factors that influence on transplantation fate is cord blood (CB) cell count, in addition to human leukocyte antigen similarity and CD34+ cell number. Here, we review the factors that could effect on quality and quantity of CBUs. Relevant English-language literatures were searched and retrieved from PubMed using the terms: CB, quality, collection, and transplantation. The numbers of total nucleated cells (TNCs) and CD34+ cells are good indicators of CB quality because they have been associated with engraftment; thereby, whatever the TNCs in a CB unit (CBU) are higher, more likely they led to successful engraftment. Many factors influence the quantity and quality of UCB units that collect after delivery. Some parameters are not in our hands, such as maternal and infant factors, and hence, we cannot change these. However, some other factors are in our authority, such as mode of collection, type and amount of anticoagulant, and time and temperature during collection to postthaw CBUs and freeze-and-thaw procedures. By optimizing the CB collection, we can improve the quantity and quality of UCB for storage and increase the likelihood of its use for transplantation.
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spelling pubmed-69100412020-01-02 Umbilical cord blood quality and quantity: Collection up to transplantation Mousavi, Seyed Hadi Zarrabi, Morteza Abroun, Saeid Ahmadipanah, Mona Abbaspanah, Bahareh Asian J Transfus Sci Review Article Umbilical cord blood (UCB) is an attractive source of hematopoietic stem cells for transplantation in some blood disorders. One of the major factors that influence on transplantation fate is cord blood (CB) cell count, in addition to human leukocyte antigen similarity and CD34+ cell number. Here, we review the factors that could effect on quality and quantity of CBUs. Relevant English-language literatures were searched and retrieved from PubMed using the terms: CB, quality, collection, and transplantation. The numbers of total nucleated cells (TNCs) and CD34+ cells are good indicators of CB quality because they have been associated with engraftment; thereby, whatever the TNCs in a CB unit (CBU) are higher, more likely they led to successful engraftment. Many factors influence the quantity and quality of UCB units that collect after delivery. Some parameters are not in our hands, such as maternal and infant factors, and hence, we cannot change these. However, some other factors are in our authority, such as mode of collection, type and amount of anticoagulant, and time and temperature during collection to postthaw CBUs and freeze-and-thaw procedures. By optimizing the CB collection, we can improve the quantity and quality of UCB for storage and increase the likelihood of its use for transplantation. Wolters Kluwer - Medknow 2019 2019-12-03 /pmc/articles/PMC6910041/ /pubmed/31896912 http://dx.doi.org/10.4103/ajts.AJTS_124_18 Text en Copyright: © 2019 Asian Journal of Transfusion Science http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Mousavi, Seyed Hadi
Zarrabi, Morteza
Abroun, Saeid
Ahmadipanah, Mona
Abbaspanah, Bahareh
Umbilical cord blood quality and quantity: Collection up to transplantation
title Umbilical cord blood quality and quantity: Collection up to transplantation
title_full Umbilical cord blood quality and quantity: Collection up to transplantation
title_fullStr Umbilical cord blood quality and quantity: Collection up to transplantation
title_full_unstemmed Umbilical cord blood quality and quantity: Collection up to transplantation
title_short Umbilical cord blood quality and quantity: Collection up to transplantation
title_sort umbilical cord blood quality and quantity: collection up to transplantation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910041/
https://www.ncbi.nlm.nih.gov/pubmed/31896912
http://dx.doi.org/10.4103/ajts.AJTS_124_18
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