Cargando…

Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction

AIM: The aim was to study the correlation of hepatic artery resistive index (HARI) with the portal pressure (PP) and its surrogate marker serum nitric oxide (NO) levels and to determine the validity of HARI as noninvasive indirect marker of PP in extrahepatic portal venous obstruction (EHPVO) pre- a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Abhishek, Bhatnagar, Veereshwar, Dhua, Anjan Kumar, Jana, Manisha, Singh, Archana, Malik, Rohan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910058/
https://www.ncbi.nlm.nih.gov/pubmed/31896898
http://dx.doi.org/10.4103/jiaps.JIAPS_244_18
_version_ 1783479040236060672
author Gupta, Abhishek
Bhatnagar, Veereshwar
Dhua, Anjan Kumar
Jana, Manisha
Singh, Archana
Malik, Rohan
author_facet Gupta, Abhishek
Bhatnagar, Veereshwar
Dhua, Anjan Kumar
Jana, Manisha
Singh, Archana
Malik, Rohan
author_sort Gupta, Abhishek
collection PubMed
description AIM: The aim was to study the correlation of hepatic artery resistive index (HARI) with the portal pressure (PP) and its surrogate marker serum nitric oxide (NO) levels and to determine the validity of HARI as noninvasive indirect marker of PP in extrahepatic portal venous obstruction (EHPVO) pre- and postoperatively. METHODS: A prospective study was conducted on 19 patients with EHPVO undergoing proximal lienorenal (LR) shunt or devascularization from February 2016 to January 2018. HARI, calculated from Doppler sonography, and NO were measured preoperatively and 14, 30 and 90 days postoperatively. Intraoperatively, PP was measured before splenectomy, and both PP and NO were measured postshunt. RESULTS: Mean age was 10.58 ± 2.85 years, and male:female ratio was 15:4. LR shunt was done in 16 while three patients required devascularization. There was a significant fall in the HARI (0.06 ± 0.02, P = 0.02), NO (14.31 ± 2.66 μmol/l, P < 0.001), and PP (11.81 ± 1.03 mmHg, P < 0.001) following shunt surgery. However, fall in HARI did not correlate with fall in PP. Preoperative HARI also did not correlate with preshunt/devascularization PP nor with preoperative NO. Postoperatively, HARI did not correlate with NO at 14-, 30-, and 90-day follow-up. CONCLUSION: HARI bears no correlation with PP or NO. Hence, it cannot be used as an indirect marker of PP.
format Online
Article
Text
id pubmed-6910058
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-69100582020-01-03 Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction Gupta, Abhishek Bhatnagar, Veereshwar Dhua, Anjan Kumar Jana, Manisha Singh, Archana Malik, Rohan J Indian Assoc Pediatr Surg Original Article AIM: The aim was to study the correlation of hepatic artery resistive index (HARI) with the portal pressure (PP) and its surrogate marker serum nitric oxide (NO) levels and to determine the validity of HARI as noninvasive indirect marker of PP in extrahepatic portal venous obstruction (EHPVO) pre- and postoperatively. METHODS: A prospective study was conducted on 19 patients with EHPVO undergoing proximal lienorenal (LR) shunt or devascularization from February 2016 to January 2018. HARI, calculated from Doppler sonography, and NO were measured preoperatively and 14, 30 and 90 days postoperatively. Intraoperatively, PP was measured before splenectomy, and both PP and NO were measured postshunt. RESULTS: Mean age was 10.58 ± 2.85 years, and male:female ratio was 15:4. LR shunt was done in 16 while three patients required devascularization. There was a significant fall in the HARI (0.06 ± 0.02, P = 0.02), NO (14.31 ± 2.66 μmol/l, P < 0.001), and PP (11.81 ± 1.03 mmHg, P < 0.001) following shunt surgery. However, fall in HARI did not correlate with fall in PP. Preoperative HARI also did not correlate with preshunt/devascularization PP nor with preoperative NO. Postoperatively, HARI did not correlate with NO at 14-, 30-, and 90-day follow-up. CONCLUSION: HARI bears no correlation with PP or NO. Hence, it cannot be used as an indirect marker of PP. Wolters Kluwer - Medknow 2020 2019-11-27 /pmc/articles/PMC6910058/ /pubmed/31896898 http://dx.doi.org/10.4103/jiaps.JIAPS_244_18 Text en Copyright: © 2019 Journal of Indian Association of Pediatric Surgeons http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gupta, Abhishek
Bhatnagar, Veereshwar
Dhua, Anjan Kumar
Jana, Manisha
Singh, Archana
Malik, Rohan
Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction
title Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction
title_full Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction
title_fullStr Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction
title_full_unstemmed Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction
title_short Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction
title_sort correlation of hepatic artery resistive index with portal pressure and serum nitric oxide levels in patients with extrahepatic portal vein obstruction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910058/
https://www.ncbi.nlm.nih.gov/pubmed/31896898
http://dx.doi.org/10.4103/jiaps.JIAPS_244_18
work_keys_str_mv AT guptaabhishek correlationofhepaticarteryresistiveindexwithportalpressureandserumnitricoxidelevelsinpatientswithextrahepaticportalveinobstruction
AT bhatnagarveereshwar correlationofhepaticarteryresistiveindexwithportalpressureandserumnitricoxidelevelsinpatientswithextrahepaticportalveinobstruction
AT dhuaanjankumar correlationofhepaticarteryresistiveindexwithportalpressureandserumnitricoxidelevelsinpatientswithextrahepaticportalveinobstruction
AT janamanisha correlationofhepaticarteryresistiveindexwithportalpressureandserumnitricoxidelevelsinpatientswithextrahepaticportalveinobstruction
AT singharchana correlationofhepaticarteryresistiveindexwithportalpressureandserumnitricoxidelevelsinpatientswithextrahepaticportalveinobstruction
AT malikrohan correlationofhepaticarteryresistiveindexwithportalpressureandserumnitricoxidelevelsinpatientswithextrahepaticportalveinobstruction