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Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway
BACKGROUND: Icaritin (ICT) is a prenylflavonoid derivative from Epimedium brevicornum Maxim. ICT has been shown to have neuroprotective effects. We investigate how ICT affects secretion of amyloid precursor protein (APP). METHODS: We exposed APP-PS1-HEK293 cells to ICT to investigate its effect on b...
Autores principales: | Feng, Fei, Li, Yuanyuan, Huang, Nanqu, Luo, Yong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910110/ https://www.ncbi.nlm.nih.gov/pubmed/31844591 http://dx.doi.org/10.7717/peerj.8219 |
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