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Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway

BACKGROUND: Icaritin (ICT) is a prenylflavonoid derivative from Epimedium brevicornum Maxim. ICT has been shown to have neuroprotective effects. We investigate how ICT affects secretion of amyloid precursor protein (APP). METHODS: We exposed APP-PS1-HEK293 cells to ICT to investigate its effect on b...

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Detalles Bibliográficos
Autores principales:	Feng, Fei, Li, Yuanyuan, Huang, Nanqu, Luo, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2019
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910110/ https://www.ncbi.nlm.nih.gov/pubmed/31844591 http://dx.doi.org/10.7717/peerj.8219

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