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The Role of Myocardial Mitochondrial Quality Control in Heart Failure
At present, the treatment of heart failure has entered the plateau phase, and it is necessary to thoroughly study the pathogenesis of heart failure and find out the corresponding treatment methods. Myocardial mitochondria is the main site of cardiac energy metabolism, whose dysfunction is an importa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910121/ https://www.ncbi.nlm.nih.gov/pubmed/31866862 http://dx.doi.org/10.3389/fphar.2019.01404 |
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author | Qiu, Zhiling Wei, Yi Song, Qingqiao Du, Bai Wang, Huan Chu, Yuguang Hu, Yuanhui |
author_facet | Qiu, Zhiling Wei, Yi Song, Qingqiao Du, Bai Wang, Huan Chu, Yuguang Hu, Yuanhui |
author_sort | Qiu, Zhiling |
collection | PubMed |
description | At present, the treatment of heart failure has entered the plateau phase, and it is necessary to thoroughly study the pathogenesis of heart failure and find out the corresponding treatment methods. Myocardial mitochondria is the main site of cardiac energy metabolism, whose dysfunction is an important factor leading to cardiac dysfunction and heart failure. Mitochondria are highly dynamic organelles. Continuous biogenesis, fusion, fission and mitophagy, contribute to the balance of mitochondria's morphology, quantity, and quality, which is called mitochondrial quality control. Mitochondrial quality control is the cornerstone of normal mitochondrial function and is found to play an important role in the pathological process of heart failure. Here, we provide an overview of the mechanisms of mitochondrial quality control and recent studies on mitochondrial quality control in heart failure, hoping to provide new ideas for drug development in heart failure. |
format | Online Article Text |
id | pubmed-6910121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69101212019-12-20 The Role of Myocardial Mitochondrial Quality Control in Heart Failure Qiu, Zhiling Wei, Yi Song, Qingqiao Du, Bai Wang, Huan Chu, Yuguang Hu, Yuanhui Front Pharmacol Pharmacology At present, the treatment of heart failure has entered the plateau phase, and it is necessary to thoroughly study the pathogenesis of heart failure and find out the corresponding treatment methods. Myocardial mitochondria is the main site of cardiac energy metabolism, whose dysfunction is an important factor leading to cardiac dysfunction and heart failure. Mitochondria are highly dynamic organelles. Continuous biogenesis, fusion, fission and mitophagy, contribute to the balance of mitochondria's morphology, quantity, and quality, which is called mitochondrial quality control. Mitochondrial quality control is the cornerstone of normal mitochondrial function and is found to play an important role in the pathological process of heart failure. Here, we provide an overview of the mechanisms of mitochondrial quality control and recent studies on mitochondrial quality control in heart failure, hoping to provide new ideas for drug development in heart failure. Frontiers Media S.A. 2019-12-06 /pmc/articles/PMC6910121/ /pubmed/31866862 http://dx.doi.org/10.3389/fphar.2019.01404 Text en Copyright © 2019 Qiu, Wei, Song, Du, Wang, Chu and Hu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Qiu, Zhiling Wei, Yi Song, Qingqiao Du, Bai Wang, Huan Chu, Yuguang Hu, Yuanhui The Role of Myocardial Mitochondrial Quality Control in Heart Failure |
title | The Role of Myocardial Mitochondrial Quality Control in Heart Failure |
title_full | The Role of Myocardial Mitochondrial Quality Control in Heart Failure |
title_fullStr | The Role of Myocardial Mitochondrial Quality Control in Heart Failure |
title_full_unstemmed | The Role of Myocardial Mitochondrial Quality Control in Heart Failure |
title_short | The Role of Myocardial Mitochondrial Quality Control in Heart Failure |
title_sort | role of myocardial mitochondrial quality control in heart failure |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910121/ https://www.ncbi.nlm.nih.gov/pubmed/31866862 http://dx.doi.org/10.3389/fphar.2019.01404 |
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