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Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis

BACKGROUND: Cutaneous angiosarcoma of the head and neck region is a subtype of cutaneous angiosarcoma with an unfavourable prognosis. Diagnosis is often delayed. PATENTS AND METHODS: The setting is an Academic Teaching Hospital Skin Cancer Center. Eight Caucasian patients could be identified, 5 men...

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Autores principales: Wollina, Uwe, Koch, André, Hansel, Gesina, Schönlebe, Jacqueline, Lotti, Torello, Vojvodic, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910783/
https://www.ncbi.nlm.nih.gov/pubmed/31850102
http://dx.doi.org/10.3889/oamjms.2019.763
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author Wollina, Uwe
Koch, André
Hansel, Gesina
Schönlebe, Jacqueline
Lotti, Torello
Vojvodic, Aleksandra
author_facet Wollina, Uwe
Koch, André
Hansel, Gesina
Schönlebe, Jacqueline
Lotti, Torello
Vojvodic, Aleksandra
author_sort Wollina, Uwe
collection PubMed
description BACKGROUND: Cutaneous angiosarcoma of the head and neck region is a subtype of cutaneous angiosarcoma with an unfavourable prognosis. Diagnosis is often delayed. PATENTS AND METHODS: The setting is an Academic Teaching Hospital Skin Cancer Center. Eight Caucasian patients could be identified, 5 men and 3 women. Delay to diagnosis was between 12 to 4 months (mean 7.8 ± 2.9 months). The diagnosis was confirmed in all cases by histopathology and immunohistochemistry. Hematoxylin-eosin, Giemsa, PAS, iron and reticulin stains were performed. Endothelial markers such as CD31, CD34, and Ki67 for proliferation assessment were used in all tumours. Other markers used included pan-cytokeratin (CK), CK7, CK20, ERG, CD 40 and c-MYC. Tumours were classified as localised versus multifocal or diffuse form. Tumour staging was performed according to the 8th edition of the AJCC. The mean age of patients was 79 years ± 26.4 years. The male to female ratio was 1.7. Tumour classification was diffuse in 2 patients, multilocular in one and localised in 5 patients. In 5 of 8 patients, a multimodal treatment was performed, one had radiotherapy alone, in another patient surgery was performed, and radiotherapy is planned. The mean OS was 26.4 months ± 24.5 months. CONCLUSION: Cutaneous angiosarcoma of the head and neck is an aggressive tumour with a poor prognosis. Although surgery remains a cornerstone of treatment, the tumour size at first presentation may be too large, and the elderly patients maybe not suitable for extensive surgery. Therefore, multimodal treatment with adjuvant radiotherapy and/ or chemotherapy is necessary. Multimodal treatment offers a better outcome than radiotherapy or chemotherapy alone. Stealth liposomal encapsulated doxorubicin is a therapeutic option for elderly patients with improved safety compared to conventional doxorubicin.
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spelling pubmed-69107832019-12-17 Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis Wollina, Uwe Koch, André Hansel, Gesina Schönlebe, Jacqueline Lotti, Torello Vojvodic, Aleksandra Open Access Maced J Med Sci Research Article BACKGROUND: Cutaneous angiosarcoma of the head and neck region is a subtype of cutaneous angiosarcoma with an unfavourable prognosis. Diagnosis is often delayed. PATENTS AND METHODS: The setting is an Academic Teaching Hospital Skin Cancer Center. Eight Caucasian patients could be identified, 5 men and 3 women. Delay to diagnosis was between 12 to 4 months (mean 7.8 ± 2.9 months). The diagnosis was confirmed in all cases by histopathology and immunohistochemistry. Hematoxylin-eosin, Giemsa, PAS, iron and reticulin stains were performed. Endothelial markers such as CD31, CD34, and Ki67 for proliferation assessment were used in all tumours. Other markers used included pan-cytokeratin (CK), CK7, CK20, ERG, CD 40 and c-MYC. Tumours were classified as localised versus multifocal or diffuse form. Tumour staging was performed according to the 8th edition of the AJCC. The mean age of patients was 79 years ± 26.4 years. The male to female ratio was 1.7. Tumour classification was diffuse in 2 patients, multilocular in one and localised in 5 patients. In 5 of 8 patients, a multimodal treatment was performed, one had radiotherapy alone, in another patient surgery was performed, and radiotherapy is planned. The mean OS was 26.4 months ± 24.5 months. CONCLUSION: Cutaneous angiosarcoma of the head and neck is an aggressive tumour with a poor prognosis. Although surgery remains a cornerstone of treatment, the tumour size at first presentation may be too large, and the elderly patients maybe not suitable for extensive surgery. Therefore, multimodal treatment with adjuvant radiotherapy and/ or chemotherapy is necessary. Multimodal treatment offers a better outcome than radiotherapy or chemotherapy alone. Stealth liposomal encapsulated doxorubicin is a therapeutic option for elderly patients with improved safety compared to conventional doxorubicin. Republic of Macedonia 2019-08-30 /pmc/articles/PMC6910783/ /pubmed/31850102 http://dx.doi.org/10.3889/oamjms.2019.763 Text en Copyright: © 2019 Uwe Wollina, André Koch, Gesina Hansel, Jacqueline Schönlebe, Torello Lotti, Aleksandra Vojvodic. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
spellingShingle Research Article
Wollina, Uwe
Koch, André
Hansel, Gesina
Schönlebe, Jacqueline
Lotti, Torello
Vojvodic, Aleksandra
Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis
title Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis
title_full Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis
title_fullStr Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis
title_full_unstemmed Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis
title_short Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis
title_sort cutaneous angiosarcoma of head and neck – a single-centre analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910783/
https://www.ncbi.nlm.nih.gov/pubmed/31850102
http://dx.doi.org/10.3889/oamjms.2019.763
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