Cargando…

Botulin Toxin Use in Rosacea and Facial Flushing Treatment

Botulinum toxin (BTX) is a neurotoxin derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic...

Descripción completa

Detalles Bibliográficos
Autores principales: Scala, Jacopo, Vojvodic, Aleksandra, Vojvodic, Petar, Vlaskovic-Jovicevic, Tatjana, Peric-Hajzler, Zorica, Matovic, Dusica, Dimitrijevic, Sanja, Vojvodic, Jovana, Sijan, Goran, Stepic, Nenad, Wollina, Uwe, Tirant, Michael, Thuong, Nguyen Van, Fioranelli, Massimo, Lotti, Torello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910814/
https://www.ncbi.nlm.nih.gov/pubmed/31850105
http://dx.doi.org/10.3889/oamjms.2019.784
_version_ 1783479164150480896
author Scala, Jacopo
Vojvodic, Aleksandra
Vojvodic, Petar
Vlaskovic-Jovicevic, Tatjana
Peric-Hajzler, Zorica
Matovic, Dusica
Dimitrijevic, Sanja
Vojvodic, Jovana
Sijan, Goran
Stepic, Nenad
Wollina, Uwe
Tirant, Michael
Thuong, Nguyen Van
Fioranelli, Massimo
Lotti, Torello
author_facet Scala, Jacopo
Vojvodic, Aleksandra
Vojvodic, Petar
Vlaskovic-Jovicevic, Tatjana
Peric-Hajzler, Zorica
Matovic, Dusica
Dimitrijevic, Sanja
Vojvodic, Jovana
Sijan, Goran
Stepic, Nenad
Wollina, Uwe
Tirant, Michael
Thuong, Nguyen Van
Fioranelli, Massimo
Lotti, Torello
author_sort Scala, Jacopo
collection PubMed
description Botulinum toxin (BTX) is a neurotoxin derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions, which include Rosacea and facial flushing treatment with good results. The complex mechanism underlying those results is not completely understood but was proposed a release inhibition of acetylcholine from peripheral autonomic nerves of the cutaneous vasodilatory system combined with the blockade substance P and calcitonin gene-related peptide (CGRP) thus modulating blood vessel dilatation. We analysed the published data on BTX off label applications rosacea and flushing retrieved from PubMed.
format Online
Article
Text
id pubmed-6910814
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Republic of Macedonia
record_format MEDLINE/PubMed
spelling pubmed-69108142019-12-17 Botulin Toxin Use in Rosacea and Facial Flushing Treatment Scala, Jacopo Vojvodic, Aleksandra Vojvodic, Petar Vlaskovic-Jovicevic, Tatjana Peric-Hajzler, Zorica Matovic, Dusica Dimitrijevic, Sanja Vojvodic, Jovana Sijan, Goran Stepic, Nenad Wollina, Uwe Tirant, Michael Thuong, Nguyen Van Fioranelli, Massimo Lotti, Torello Open Access Maced J Med Sci Review Article Botulinum toxin (BTX) is a neurotoxin derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions, which include Rosacea and facial flushing treatment with good results. The complex mechanism underlying those results is not completely understood but was proposed a release inhibition of acetylcholine from peripheral autonomic nerves of the cutaneous vasodilatory system combined with the blockade substance P and calcitonin gene-related peptide (CGRP) thus modulating blood vessel dilatation. We analysed the published data on BTX off label applications rosacea and flushing retrieved from PubMed. Republic of Macedonia 2019-08-30 /pmc/articles/PMC6910814/ /pubmed/31850105 http://dx.doi.org/10.3889/oamjms.2019.784 Text en Copyright: © 2019 Jacopo Scala, Aleksandra Vojvodic, Petar Vojvodic, Tatjana Vlaskovic-Jovicevic, Zorica Peric-Hajzler, Dusica Matovic, Sanja Dimitrijevic, Jovana Vojvodic, Goran Sijan, Nenad Stepic, Uwe Wollina, Michael Tirant, Nguyen Van Thuong, Massimo Fioranelli, Torello Lotti. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
spellingShingle Review Article
Scala, Jacopo
Vojvodic, Aleksandra
Vojvodic, Petar
Vlaskovic-Jovicevic, Tatjana
Peric-Hajzler, Zorica
Matovic, Dusica
Dimitrijevic, Sanja
Vojvodic, Jovana
Sijan, Goran
Stepic, Nenad
Wollina, Uwe
Tirant, Michael
Thuong, Nguyen Van
Fioranelli, Massimo
Lotti, Torello
Botulin Toxin Use in Rosacea and Facial Flushing Treatment
title Botulin Toxin Use in Rosacea and Facial Flushing Treatment
title_full Botulin Toxin Use in Rosacea and Facial Flushing Treatment
title_fullStr Botulin Toxin Use in Rosacea and Facial Flushing Treatment
title_full_unstemmed Botulin Toxin Use in Rosacea and Facial Flushing Treatment
title_short Botulin Toxin Use in Rosacea and Facial Flushing Treatment
title_sort botulin toxin use in rosacea and facial flushing treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910814/
https://www.ncbi.nlm.nih.gov/pubmed/31850105
http://dx.doi.org/10.3889/oamjms.2019.784
work_keys_str_mv AT scalajacopo botulintoxinuseinrosaceaandfacialflushingtreatment
AT vojvodicaleksandra botulintoxinuseinrosaceaandfacialflushingtreatment
AT vojvodicpetar botulintoxinuseinrosaceaandfacialflushingtreatment
AT vlaskovicjovicevictatjana botulintoxinuseinrosaceaandfacialflushingtreatment
AT perichajzlerzorica botulintoxinuseinrosaceaandfacialflushingtreatment
AT matovicdusica botulintoxinuseinrosaceaandfacialflushingtreatment
AT dimitrijevicsanja botulintoxinuseinrosaceaandfacialflushingtreatment
AT vojvodicjovana botulintoxinuseinrosaceaandfacialflushingtreatment
AT sijangoran botulintoxinuseinrosaceaandfacialflushingtreatment
AT stepicnenad botulintoxinuseinrosaceaandfacialflushingtreatment
AT wollinauwe botulintoxinuseinrosaceaandfacialflushingtreatment
AT tirantmichael botulintoxinuseinrosaceaandfacialflushingtreatment
AT thuongnguyenvan botulintoxinuseinrosaceaandfacialflushingtreatment
AT fioranellimassimo botulintoxinuseinrosaceaandfacialflushingtreatment
AT lottitorello botulintoxinuseinrosaceaandfacialflushingtreatment