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Melanoma and Mastocytosis

There are numerous cases reports and studies confirming the enhanced incidence of melanoma among patients with mastocytosis, especially with systemic mastocytosis. These two diseases are arising from two different types of cells; melanoma arises from neural crest cells and mastocytosis from hematopo...

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Autores principales: Vojvodic, Aleksandra, Vlaskovic-Jovicevic, Tatjana, Vojvodic, Petar, Vojvodic, Jovana, Goldust, Mohamad, Peric-Hajzler, Zorica, Matovic, Dusica, Sijan, Goran, Stepic, Nenad, Wollina, Uwe, Fioranelli, Massimo, Tirant, Michael, Nguyen, Van Thuong, Lotti, Torello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910818/
https://www.ncbi.nlm.nih.gov/pubmed/31850121
http://dx.doi.org/10.3889/oamjms.2019.772
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author Vojvodic, Aleksandra
Vlaskovic-Jovicevic, Tatjana
Vojvodic, Petar
Vojvodic, Jovana
Goldust, Mohamad
Peric-Hajzler, Zorica
Matovic, Dusica
Sijan, Goran
Stepic, Nenad
Wollina, Uwe
Fioranelli, Massimo
Tirant, Michael
Nguyen, Van Thuong
Lotti, Torello
author_facet Vojvodic, Aleksandra
Vlaskovic-Jovicevic, Tatjana
Vojvodic, Petar
Vojvodic, Jovana
Goldust, Mohamad
Peric-Hajzler, Zorica
Matovic, Dusica
Sijan, Goran
Stepic, Nenad
Wollina, Uwe
Fioranelli, Massimo
Tirant, Michael
Nguyen, Van Thuong
Lotti, Torello
author_sort Vojvodic, Aleksandra
collection PubMed
description There are numerous cases reports and studies confirming the enhanced incidence of melanoma among patients with mastocytosis, especially with systemic mastocytosis. These two diseases are arising from two different types of cells; melanoma arises from neural crest cells and mastocytosis from hematopoietic stem cells. But there are a lot of similarities between the two diseases. The most important and significant is the dependence of the growth factor receptor c-KIT and c-KIT ligand (stem cell factor) for their growth and development. Also, expression of the STAT3 (signal transducer and activator of transcription 3) and transcription factors MITF (microphthalmia-associated transcription factor) make the connection between melanoma and mastocytosis.
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spelling pubmed-69108182019-12-17 Melanoma and Mastocytosis Vojvodic, Aleksandra Vlaskovic-Jovicevic, Tatjana Vojvodic, Petar Vojvodic, Jovana Goldust, Mohamad Peric-Hajzler, Zorica Matovic, Dusica Sijan, Goran Stepic, Nenad Wollina, Uwe Fioranelli, Massimo Tirant, Michael Nguyen, Van Thuong Lotti, Torello Open Access Maced J Med Sci Review Article There are numerous cases reports and studies confirming the enhanced incidence of melanoma among patients with mastocytosis, especially with systemic mastocytosis. These two diseases are arising from two different types of cells; melanoma arises from neural crest cells and mastocytosis from hematopoietic stem cells. But there are a lot of similarities between the two diseases. The most important and significant is the dependence of the growth factor receptor c-KIT and c-KIT ligand (stem cell factor) for their growth and development. Also, expression of the STAT3 (signal transducer and activator of transcription 3) and transcription factors MITF (microphthalmia-associated transcription factor) make the connection between melanoma and mastocytosis. Republic of Macedonia 2019-08-30 /pmc/articles/PMC6910818/ /pubmed/31850121 http://dx.doi.org/10.3889/oamjms.2019.772 Text en Copyright: © 2019 Aleksandra Vojvodic, Tatjana Vlaskovic Jovicevic, Petar Vojvodic, Jovana Vojvodic, Mohamad Goldust, Zorica Peric Hajzler, Dusica Matovic, Goran Sijan, Nenad Stepic, Uwe Wollina, Massimo Fioranelli, Michael Tirant, Van Thuong Nguyen, Torello Lotti. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
spellingShingle Review Article
Vojvodic, Aleksandra
Vlaskovic-Jovicevic, Tatjana
Vojvodic, Petar
Vojvodic, Jovana
Goldust, Mohamad
Peric-Hajzler, Zorica
Matovic, Dusica
Sijan, Goran
Stepic, Nenad
Wollina, Uwe
Fioranelli, Massimo
Tirant, Michael
Nguyen, Van Thuong
Lotti, Torello
Melanoma and Mastocytosis
title Melanoma and Mastocytosis
title_full Melanoma and Mastocytosis
title_fullStr Melanoma and Mastocytosis
title_full_unstemmed Melanoma and Mastocytosis
title_short Melanoma and Mastocytosis
title_sort melanoma and mastocytosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910818/
https://www.ncbi.nlm.nih.gov/pubmed/31850121
http://dx.doi.org/10.3889/oamjms.2019.772
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