Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment

The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartme...

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Autores principales: Riou, Catherine, Jhilmeet, Nishtha, Rangaka, Molebogeng X, Wilkinson, Robert J, Wilkinson, Katalin A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910879/
https://www.ncbi.nlm.nih.gov/pubmed/31419285
http://dx.doi.org/10.1093/infdis/jiz417
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author Riou, Catherine
Jhilmeet, Nishtha
Rangaka, Molebogeng X
Wilkinson, Robert J
Wilkinson, Katalin A
author_facet Riou, Catherine
Jhilmeet, Nishtha
Rangaka, Molebogeng X
Wilkinson, Robert J
Wilkinson, Katalin A
author_sort Riou, Catherine
collection PubMed
description The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-γ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses.
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spelling pubmed-69108792019-12-18 Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment Riou, Catherine Jhilmeet, Nishtha Rangaka, Molebogeng X Wilkinson, Robert J Wilkinson, Katalin A J Infect Dis Major Articles and Brief Reports The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-γ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses. Oxford University Press 2020-01-01 2019-08-17 /pmc/articles/PMC6910879/ /pubmed/31419285 http://dx.doi.org/10.1093/infdis/jiz417 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Riou, Catherine
Jhilmeet, Nishtha
Rangaka, Molebogeng X
Wilkinson, Robert J
Wilkinson, Katalin A
Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
title Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
title_full Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
title_fullStr Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
title_full_unstemmed Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
title_short Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
title_sort tuberculosis antigen-specific t-cell responses during the first 6 months of antiretroviral treatment
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910879/
https://www.ncbi.nlm.nih.gov/pubmed/31419285
http://dx.doi.org/10.1093/infdis/jiz417
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