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Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4

Npl4 is likely to be the most upstream factor recognizing Lys48-linked polyubiquitylated substrates in the proteasomal degradation pathway in yeast. Along with Ufd1, Npl4 forms a heterodimer (UN), and functions as a cofactor for the Cdc48 ATPase. Here, we report the crystal structures of yeast Npl4...

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Detalles Bibliográficos
Autores principales:	Sato, Yusuke, Tsuchiya, Hikaru, Yamagata, Atsushi, Okatsu, Kei, Tanaka, Keiji, Saeki, Yasushi, Fukai, Shuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910952/ https://www.ncbi.nlm.nih.gov/pubmed/31836717 http://dx.doi.org/10.1038/s41467-019-13697-y

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