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Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease

Literature documents the impact of Parkinson’s Disease (PD) on speech but no study has analyzed in detail the importance of the distinct phonemic groups for the automatic identification of the disease. This study presents new approaches that are evaluated in three different corpora containing speake...

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Autores principales: Moro-Velazquez, Laureano, Gomez-Garcia, Jorge A., Godino-Llorente, Juan I., Grandas-Perez, Francisco, Shattuck-Hufnagel, Stefanie, Yagüe-Jimenez, Virginia, Dehak, Najim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910953/
https://www.ncbi.nlm.nih.gov/pubmed/31836744
http://dx.doi.org/10.1038/s41598-019-55271-y
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author Moro-Velazquez, Laureano
Gomez-Garcia, Jorge A.
Godino-Llorente, Juan I.
Grandas-Perez, Francisco
Shattuck-Hufnagel, Stefanie
Yagüe-Jimenez, Virginia
Dehak, Najim
author_facet Moro-Velazquez, Laureano
Gomez-Garcia, Jorge A.
Godino-Llorente, Juan I.
Grandas-Perez, Francisco
Shattuck-Hufnagel, Stefanie
Yagüe-Jimenez, Virginia
Dehak, Najim
author_sort Moro-Velazquez, Laureano
collection PubMed
description Literature documents the impact of Parkinson’s Disease (PD) on speech but no study has analyzed in detail the importance of the distinct phonemic groups for the automatic identification of the disease. This study presents new approaches that are evaluated in three different corpora containing speakers suffering from PD with two main objectives: to investigate the influence of the different phonemic groups in the detection of PD and to propose more accurate detection schemes employing speech. The proposed methodology uses GMM-UBM classifiers combined with a technique introduced in this paper called phonemic grouping, that permits observation of the differences in accuracy depending on the manner of articulation. Cross-validation results reach accuracies between 85% and 94% with AUC ranging from 0.91 to 0.98, while cross-corpora trials yield accuracies between 75% and 82% with AUC between 0.84 and 0.95, depending on the corpus. This is the first work analyzing the generalization properties of the proposed approaches employing cross-corpora trials and reaching high accuracies. Among the different phonemic groups, results suggest that plosives, vowels and fricatives are the most relevant acoustic segments for the detection of PD with the proposed schemes. In addition, the use of text-dependent utterances leads to more consistent and accurate models.
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spelling pubmed-69109532019-12-16 Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease Moro-Velazquez, Laureano Gomez-Garcia, Jorge A. Godino-Llorente, Juan I. Grandas-Perez, Francisco Shattuck-Hufnagel, Stefanie Yagüe-Jimenez, Virginia Dehak, Najim Sci Rep Article Literature documents the impact of Parkinson’s Disease (PD) on speech but no study has analyzed in detail the importance of the distinct phonemic groups for the automatic identification of the disease. This study presents new approaches that are evaluated in three different corpora containing speakers suffering from PD with two main objectives: to investigate the influence of the different phonemic groups in the detection of PD and to propose more accurate detection schemes employing speech. The proposed methodology uses GMM-UBM classifiers combined with a technique introduced in this paper called phonemic grouping, that permits observation of the differences in accuracy depending on the manner of articulation. Cross-validation results reach accuracies between 85% and 94% with AUC ranging from 0.91 to 0.98, while cross-corpora trials yield accuracies between 75% and 82% with AUC between 0.84 and 0.95, depending on the corpus. This is the first work analyzing the generalization properties of the proposed approaches employing cross-corpora trials and reaching high accuracies. Among the different phonemic groups, results suggest that plosives, vowels and fricatives are the most relevant acoustic segments for the detection of PD with the proposed schemes. In addition, the use of text-dependent utterances leads to more consistent and accurate models. Nature Publishing Group UK 2019-12-13 /pmc/articles/PMC6910953/ /pubmed/31836744 http://dx.doi.org/10.1038/s41598-019-55271-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Moro-Velazquez, Laureano
Gomez-Garcia, Jorge A.
Godino-Llorente, Juan I.
Grandas-Perez, Francisco
Shattuck-Hufnagel, Stefanie
Yagüe-Jimenez, Virginia
Dehak, Najim
Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease
title Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease
title_full Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease
title_fullStr Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease
title_full_unstemmed Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease
title_short Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s Disease
title_sort phonetic relevance and phonemic grouping of speech in the automatic detection of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910953/
https://www.ncbi.nlm.nih.gov/pubmed/31836744
http://dx.doi.org/10.1038/s41598-019-55271-y
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