The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid polypeptide (hIAPP) into cytotoxic amyloid species. Here we tested the effect of a diphenylpyrazole (DPP)-derived small molecule inhibitor, anle145c, on cytotoxicity and on aggregation properties of hIAPP. We demonstrat...

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Detalles Bibliográficos
Autores principales: Saravanan, Manikam S., Ryazanov, Sergey, Leonov, Andrei, Nicolai, Janine, Praest, Patrique, Giese, Armin, Winter, Roland, Khemtemourian, Lucie, Griesinger, Christian, Killian, J. Antoinette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911113/
https://www.ncbi.nlm.nih.gov/pubmed/31836748
http://dx.doi.org/10.1038/s41598-019-54919-z

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