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Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review

Low-grade chondrosarcoma (LGC) is a very rare intracranial tumor, particularly in the sellar area. Herein, we describe an unusual case of LGC occurring in the sellar area. A 52-year-old man presented with diminution of vision for more than 3 months, but did not exhibit headaches reported in previous...

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Autores principales: Zhang, Zhen, Pang, Li-Juan, Wang, Ning, Li, Zhong, Cao, Yu-Wen, Hu, Wen-Hao, Liang, Wei-Hua, Jiang, Jin-Fang, Zou, Hong, Qi, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911348/
https://www.ncbi.nlm.nih.gov/pubmed/31849484
http://dx.doi.org/10.2147/OTT.S221898
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author Zhang, Zhen
Pang, Li-Juan
Wang, Ning
Li, Zhong
Cao, Yu-Wen
Hu, Wen-Hao
Liang, Wei-Hua
Jiang, Jin-Fang
Zou, Hong
Qi, Yan
author_facet Zhang, Zhen
Pang, Li-Juan
Wang, Ning
Li, Zhong
Cao, Yu-Wen
Hu, Wen-Hao
Liang, Wei-Hua
Jiang, Jin-Fang
Zou, Hong
Qi, Yan
author_sort Zhang, Zhen
collection PubMed
description Low-grade chondrosarcoma (LGC) is a very rare intracranial tumor, particularly in the sellar area. Herein, we describe an unusual case of LGC occurring in the sellar area. A 52-year-old man presented with diminution of vision for more than 3 months, but did not exhibit headaches reported in previous cases. MRI showed that the maximum size of the tumor was 7 cm on the left side of the saddle. We characterized the specific pathological characteristics. Histologically, the tumor had polypoid areas and a lobulated growth pattern under low-power examination. At high magnification, the tumor consisted of small cells with hyperchromatic nuclei in the cartilage matrix, with an alternating loose hypocellular zone and rich myxoid area. In our case, LGC needed to be distinguished from chordoma. Immunohistochemically, the tumor cells showed diffuse positivity for S-100 and vimentin, IDH1 was weakly cytoplasm positive. The Ki-67 labeling index was less than 5%. Additionally, AE1/3, EMA, and CK19 were negative, which could be used to exclude chordoma. This case report expands the literature on LGC and will help clinicians and pathologists better understand this entity.
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spelling pubmed-69113482019-12-17 Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review Zhang, Zhen Pang, Li-Juan Wang, Ning Li, Zhong Cao, Yu-Wen Hu, Wen-Hao Liang, Wei-Hua Jiang, Jin-Fang Zou, Hong Qi, Yan Onco Targets Ther Case Report Low-grade chondrosarcoma (LGC) is a very rare intracranial tumor, particularly in the sellar area. Herein, we describe an unusual case of LGC occurring in the sellar area. A 52-year-old man presented with diminution of vision for more than 3 months, but did not exhibit headaches reported in previous cases. MRI showed that the maximum size of the tumor was 7 cm on the left side of the saddle. We characterized the specific pathological characteristics. Histologically, the tumor had polypoid areas and a lobulated growth pattern under low-power examination. At high magnification, the tumor consisted of small cells with hyperchromatic nuclei in the cartilage matrix, with an alternating loose hypocellular zone and rich myxoid area. In our case, LGC needed to be distinguished from chordoma. Immunohistochemically, the tumor cells showed diffuse positivity for S-100 and vimentin, IDH1 was weakly cytoplasm positive. The Ki-67 labeling index was less than 5%. Additionally, AE1/3, EMA, and CK19 were negative, which could be used to exclude chordoma. This case report expands the literature on LGC and will help clinicians and pathologists better understand this entity. Dove 2019-12-10 /pmc/articles/PMC6911348/ /pubmed/31849484 http://dx.doi.org/10.2147/OTT.S221898 Text en © 2019 Zhang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Zhang, Zhen
Pang, Li-Juan
Wang, Ning
Li, Zhong
Cao, Yu-Wen
Hu, Wen-Hao
Liang, Wei-Hua
Jiang, Jin-Fang
Zou, Hong
Qi, Yan
Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
title Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
title_full Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
title_fullStr Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
title_full_unstemmed Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
title_short Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
title_sort low-grade chondrosarcoma in the sellar area: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911348/
https://www.ncbi.nlm.nih.gov/pubmed/31849484
http://dx.doi.org/10.2147/OTT.S221898
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