Folic acid supplementation reduces multigenerational sperm miRNA perturbation induced by in utero environmental contaminant exposure

Persistent organic pollutants (POPs) can induce epigenetic changes in the paternal germline. Here, we report that folic acid (FA) supplementation mitigates sperm miRNA profiles transgenerationally following in utero paternal exposure to POPs in a rat model. Pregnant founder dams were exposed to an e...

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Detalles Bibliográficos
Autores principales: Herst, P M, Dalvai, M, Lessard, M, Charest, P L, Navarro, P, Joly-Beauparlant, C, Droit, A, Trasler, J M, Kimmins, S, MacFarlane, A J, Benoit-Biancamano, M-O, Bailey, J L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911352/
https://www.ncbi.nlm.nih.gov/pubmed/31853372
http://dx.doi.org/10.1093/eep/dvz024

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