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Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine
We herein report the first case in which an escalated dose of sunitinib was effective, even after dose reduction. A 64-year-old man with gastrointestinal stromal tumor of the small intestine discontinued adjuvant imatinib because of interstitial pneumonia. After two years, peritoneal recurrence was...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911760/ https://www.ncbi.nlm.nih.gov/pubmed/31327822 http://dx.doi.org/10.2169/internalmedicine.2806-19 |
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author | Ogata, Misato Satake, Hironaga Ogata, Takatsugu Hatachi, Yukimasa Hara, Shigeo Hirota, Seiichi Yasui, Hisateru |
author_facet | Ogata, Misato Satake, Hironaga Ogata, Takatsugu Hatachi, Yukimasa Hara, Shigeo Hirota, Seiichi Yasui, Hisateru |
author_sort | Ogata, Misato |
collection | PubMed |
description | We herein report the first case in which an escalated dose of sunitinib was effective, even after dose reduction. A 64-year-old man with gastrointestinal stromal tumor of the small intestine discontinued adjuvant imatinib because of interstitial pneumonia. After two years, peritoneal recurrence was detected. Sunitinib was started at 50 mg/day for 4 weeks every 6 weeks, after which the dosage was reduced to 37.5 mg/day because of grade 1 gastritis, stomatitis, and a fever. Four months later, computed tomography showed progressive disease. As the adverse events were well-controlled by medication, we escalated the dose to 50 mg/day and achieved a partial response. |
format | Online Article Text |
id | pubmed-6911760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-69117602019-12-16 Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine Ogata, Misato Satake, Hironaga Ogata, Takatsugu Hatachi, Yukimasa Hara, Shigeo Hirota, Seiichi Yasui, Hisateru Intern Med Case Report We herein report the first case in which an escalated dose of sunitinib was effective, even after dose reduction. A 64-year-old man with gastrointestinal stromal tumor of the small intestine discontinued adjuvant imatinib because of interstitial pneumonia. After two years, peritoneal recurrence was detected. Sunitinib was started at 50 mg/day for 4 weeks every 6 weeks, after which the dosage was reduced to 37.5 mg/day because of grade 1 gastritis, stomatitis, and a fever. Four months later, computed tomography showed progressive disease. As the adverse events were well-controlled by medication, we escalated the dose to 50 mg/day and achieved a partial response. The Japanese Society of Internal Medicine 2019-07-22 2019-11-15 /pmc/articles/PMC6911760/ /pubmed/31327822 http://dx.doi.org/10.2169/internalmedicine.2806-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Ogata, Misato Satake, Hironaga Ogata, Takatsugu Hatachi, Yukimasa Hara, Shigeo Hirota, Seiichi Yasui, Hisateru Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine |
title | Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine |
title_full | Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine |
title_fullStr | Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine |
title_full_unstemmed | Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine |
title_short | Reduction and Escalation in the Dose of Sunitinib Were Adequately Effective against Gastrointestinal Stromal Tumor of the Small Intestine |
title_sort | reduction and escalation in the dose of sunitinib were adequately effective against gastrointestinal stromal tumor of the small intestine |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911760/ https://www.ncbi.nlm.nih.gov/pubmed/31327822 http://dx.doi.org/10.2169/internalmedicine.2806-19 |
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