Cargando…
Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis
A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a bio...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Japanese Society of Internal Medicine
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911763/ https://www.ncbi.nlm.nih.gov/pubmed/31327821 http://dx.doi.org/10.2169/internalmedicine.2782-19 |
| _version_ | 1783479319801102336 |
|---|---|
| author | Toyama, Shiho Takatani, Ayuko Koga, Tomohiro Eguchi, Mizuna Okamoto, Momoko Tsuji, Sosuke Endo, Yushiro Shimizu, Toshimasa Sumiyoshi, Remi Igawa, Takashi Kawashiri, Shin-ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Nakamura, Hideki Origuchi, Tomoki Furuyama, Masako Tabuchi, Maiko Kobayashi, Shinichiro Kanetaka, Kengo Hashisako, Mikiko Abe, Kuniko Niino, Daisuke Sato, Shinya Miyazaki, Yasushi Kawakami, Atsushi |
| author_facet | Toyama, Shiho Takatani, Ayuko Koga, Tomohiro Eguchi, Mizuna Okamoto, Momoko Tsuji, Sosuke Endo, Yushiro Shimizu, Toshimasa Sumiyoshi, Remi Igawa, Takashi Kawashiri, Shin-ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Nakamura, Hideki Origuchi, Tomoki Furuyama, Masako Tabuchi, Maiko Kobayashi, Shinichiro Kanetaka, Kengo Hashisako, Mikiko Abe, Kuniko Niino, Daisuke Sato, Shinya Miyazaki, Yasushi Kawakami, Atsushi |
| author_sort | Toyama, Shiho |
| collection | PubMed |
| description | A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment. |
| format | Online Article Text |
| id | pubmed-6911763 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | The Japanese Society of Internal Medicine |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69117632019-12-16 Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis Toyama, Shiho Takatani, Ayuko Koga, Tomohiro Eguchi, Mizuna Okamoto, Momoko Tsuji, Sosuke Endo, Yushiro Shimizu, Toshimasa Sumiyoshi, Remi Igawa, Takashi Kawashiri, Shin-ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Nakamura, Hideki Origuchi, Tomoki Furuyama, Masako Tabuchi, Maiko Kobayashi, Shinichiro Kanetaka, Kengo Hashisako, Mikiko Abe, Kuniko Niino, Daisuke Sato, Shinya Miyazaki, Yasushi Kawakami, Atsushi Intern Med Case Report A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment. The Japanese Society of Internal Medicine 2019-07-22 2019-11-15 /pmc/articles/PMC6911763/ /pubmed/31327821 http://dx.doi.org/10.2169/internalmedicine.2782-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Case Report Toyama, Shiho Takatani, Ayuko Koga, Tomohiro Eguchi, Mizuna Okamoto, Momoko Tsuji, Sosuke Endo, Yushiro Shimizu, Toshimasa Sumiyoshi, Remi Igawa, Takashi Kawashiri, Shin-ya Iwamoto, Naoki Ichinose, Kunihiro Tamai, Mami Nakamura, Hideki Origuchi, Tomoki Furuyama, Masako Tabuchi, Maiko Kobayashi, Shinichiro Kanetaka, Kengo Hashisako, Mikiko Abe, Kuniko Niino, Daisuke Sato, Shinya Miyazaki, Yasushi Kawakami, Atsushi Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis |
| title | Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis |
| title_full | Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis |
| title_fullStr | Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis |
| title_full_unstemmed | Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis |
| title_short | Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis |
| title_sort | gastric perforation due to iatrogenic immunodeficiency-associated lymphoproliferative disorder during the treatment of rheumatoid arthritis |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911763/ https://www.ncbi.nlm.nih.gov/pubmed/31327821 http://dx.doi.org/10.2169/internalmedicine.2782-19 |
| work_keys_str_mv | AT toyamashiho gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT takataniayuko gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT kogatomohiro gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT eguchimizuna gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT okamotomomoko gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT tsujisosuke gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT endoyushiro gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT shimizutoshimasa gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT sumiyoshiremi gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT igawatakashi gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT kawashirishinya gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT iwamotonaoki gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT ichinosekunihiro gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT tamaimami gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT nakamurahideki gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT origuchitomoki gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT furuyamamasako gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT tabuchimaiko gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT kobayashishinichiro gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT kanetakakengo gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT hashisakomikiko gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT abekuniko gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT niinodaisuke gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT satoshinya gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT miyazakiyasushi gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis AT kawakamiatsushi gastricperforationduetoiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderduringthetreatmentofrheumatoidarthritis |