Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation

Disturbance of the normal gut microbiota has been implicated in the pathogenesis of various diseases, including chronic kidney disease (CKD). A common CKD symptom is chronic constipation. Lubiprostone is a safe and efficacious drug for treating chronic constipation. We herein report 2 patients with...

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Autores principales: Takeshita, Mitsuhide, Tanaka, Atsushi, Nakamura, Tsukasa, Sato, Eiichi, Node, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911766/
https://www.ncbi.nlm.nih.gov/pubmed/31292404
http://dx.doi.org/10.2169/internalmedicine.3158-19
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author Takeshita, Mitsuhide
Tanaka, Atsushi
Nakamura, Tsukasa
Sato, Eiichi
Node, Koichi
author_facet Takeshita, Mitsuhide
Tanaka, Atsushi
Nakamura, Tsukasa
Sato, Eiichi
Node, Koichi
author_sort Takeshita, Mitsuhide
collection PubMed
description Disturbance of the normal gut microbiota has been implicated in the pathogenesis of various diseases, including chronic kidney disease (CKD). A common CKD symptom is chronic constipation. Lubiprostone is a safe and efficacious drug for treating chronic constipation. We herein report 2 patients with IgA nephropathy treated with lubiprostone (24 μg 1×/day). The lubiprostone treatment ameliorated their chronic constipation and, unexpectedly, reduced the urinary protein excretion, urinary liver-type fatty acid binding protein and urine occult blood. These results may indicate that lubiprostone is a useful therapeutic intervention against the progression of IgA nephropathy with chronic constipation.
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spelling pubmed-69117662019-12-16 Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation Takeshita, Mitsuhide Tanaka, Atsushi Nakamura, Tsukasa Sato, Eiichi Node, Koichi Intern Med Case Report Disturbance of the normal gut microbiota has been implicated in the pathogenesis of various diseases, including chronic kidney disease (CKD). A common CKD symptom is chronic constipation. Lubiprostone is a safe and efficacious drug for treating chronic constipation. We herein report 2 patients with IgA nephropathy treated with lubiprostone (24 μg 1×/day). The lubiprostone treatment ameliorated their chronic constipation and, unexpectedly, reduced the urinary protein excretion, urinary liver-type fatty acid binding protein and urine occult blood. These results may indicate that lubiprostone is a useful therapeutic intervention against the progression of IgA nephropathy with chronic constipation. The Japanese Society of Internal Medicine 2019-07-10 2019-11-15 /pmc/articles/PMC6911766/ /pubmed/31292404 http://dx.doi.org/10.2169/internalmedicine.3158-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takeshita, Mitsuhide
Tanaka, Atsushi
Nakamura, Tsukasa
Sato, Eiichi
Node, Koichi
Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation
title Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation
title_full Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation
title_fullStr Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation
title_full_unstemmed Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation
title_short Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation
title_sort effect of lubiprostone on urinary protein excretion: a report of two iga nephropathy patients with chronic constipation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911766/
https://www.ncbi.nlm.nih.gov/pubmed/31292404
http://dx.doi.org/10.2169/internalmedicine.3158-19
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