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Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes

PURPOSE: To explore the progressive change and associated factors of optic disc tilt in young myopic glaucomatous eyes by analyzing long-term follow-up data. METHODS: Optic disc images were obtained from spectral-domain optical coherence tomography enhanced depth imaging from at least five different...

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Autores principales: Yoon, Joo Young, Sung, Kyung Rim, Yun, Sung-Cheol, Shin, Joong Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Ophthalmological Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911789/
https://www.ncbi.nlm.nih.gov/pubmed/31833249
http://dx.doi.org/10.3341/kjo.2019.0069
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author Yoon, Joo Young
Sung, Kyung Rim
Yun, Sung-Cheol
Shin, Joong Won
author_facet Yoon, Joo Young
Sung, Kyung Rim
Yun, Sung-Cheol
Shin, Joong Won
author_sort Yoon, Joo Young
collection PubMed
description PURPOSE: To explore the progressive change and associated factors of optic disc tilt in young myopic glaucomatous eyes by analyzing long-term follow-up data. METHODS: Optic disc images were obtained from spectral-domain optical coherence tomography enhanced depth imaging from at least five different visits. At each visit, the disc tilt angle (DTA), defined as the angle between the Bruch's membrane opening plane and the optic canal plane, was estimated at the central frame that passes through the optic disc. Glaucoma progression was assessed on the basis of changes noted on serial optic disc and retinal nerve fiber layer photographs or changes in the visual field (VF). A linear mixed effect model was used to assess the influence of parameters (age, sex, baseline and follow-up intraocular pressure, retinal nerve fiber layer thickness, VF mean deviation, axial length, central corneal thickness), and presence of glaucomatous progression upon DTA change. RESULTS: A total of 26 eyes of 26 young myopic primary open-angle glaucoma patients (axial length >24.0 mm; mean age, 25.1 ± 4.0 years; mean follow-up, 3.3 ± 0.9 years) were included. DTA was 7.0 ± 3.4 degrees at baseline and 8.3 ± 3.8 degrees at last visit, which represents a significant difference (p < 0.001). Worse VF mean deviation (p < 0.001) and longer axial length (p = 0.006) were significantly associated with DTA increase. CONCLUSIONS: Young myopic glaucomatous eyes showed progressive optic disc tilting. Progressive optic disc tilting in young myopic glaucomatous eyes may be related to either continuous axial myopic shift or glaucomatous structural change.
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spelling pubmed-69117892019-12-29 Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes Yoon, Joo Young Sung, Kyung Rim Yun, Sung-Cheol Shin, Joong Won Korean J Ophthalmol Original Article PURPOSE: To explore the progressive change and associated factors of optic disc tilt in young myopic glaucomatous eyes by analyzing long-term follow-up data. METHODS: Optic disc images were obtained from spectral-domain optical coherence tomography enhanced depth imaging from at least five different visits. At each visit, the disc tilt angle (DTA), defined as the angle between the Bruch's membrane opening plane and the optic canal plane, was estimated at the central frame that passes through the optic disc. Glaucoma progression was assessed on the basis of changes noted on serial optic disc and retinal nerve fiber layer photographs or changes in the visual field (VF). A linear mixed effect model was used to assess the influence of parameters (age, sex, baseline and follow-up intraocular pressure, retinal nerve fiber layer thickness, VF mean deviation, axial length, central corneal thickness), and presence of glaucomatous progression upon DTA change. RESULTS: A total of 26 eyes of 26 young myopic primary open-angle glaucoma patients (axial length >24.0 mm; mean age, 25.1 ± 4.0 years; mean follow-up, 3.3 ± 0.9 years) were included. DTA was 7.0 ± 3.4 degrees at baseline and 8.3 ± 3.8 degrees at last visit, which represents a significant difference (p < 0.001). Worse VF mean deviation (p < 0.001) and longer axial length (p = 0.006) were significantly associated with DTA increase. CONCLUSIONS: Young myopic glaucomatous eyes showed progressive optic disc tilting. Progressive optic disc tilting in young myopic glaucomatous eyes may be related to either continuous axial myopic shift or glaucomatous structural change. The Korean Ophthalmological Society 2019-12 2019-12-05 /pmc/articles/PMC6911789/ /pubmed/31833249 http://dx.doi.org/10.3341/kjo.2019.0069 Text en © 2019 The Korean Ophthalmological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Joo Young
Sung, Kyung Rim
Yun, Sung-Cheol
Shin, Joong Won
Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes
title Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes
title_full Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes
title_fullStr Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes
title_full_unstemmed Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes
title_short Progressive Optic Disc Tilt in Young Myopic Glaucomatous Eyes
title_sort progressive optic disc tilt in young myopic glaucomatous eyes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911789/
https://www.ncbi.nlm.nih.gov/pubmed/31833249
http://dx.doi.org/10.3341/kjo.2019.0069
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