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Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation

BACKGROUND: Endothelial function, as measured by big endothelin-1 (ET-1), has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease. Nevertheless, there are little data about the association between big ET-1 and thromboembolism risk in atrial f...

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Autores principales: Zheng, Li-Hui, Liu, Shang-Yu, Hu, Feng, Liang, Er-Peng, Wu, Ling-Min, Wang, Hong-Lei, Killu, Ammar M, Yao, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911798/
https://www.ncbi.nlm.nih.gov/pubmed/31853246
http://dx.doi.org/10.11909/j.issn.1671-5411.2019.11.003
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author Zheng, Li-Hui
Liu, Shang-Yu
Hu, Feng
Liang, Er-Peng
Wu, Ling-Min
Wang, Hong-Lei
Killu, Ammar M
Yao, Yan
author_facet Zheng, Li-Hui
Liu, Shang-Yu
Hu, Feng
Liang, Er-Peng
Wu, Ling-Min
Wang, Hong-Lei
Killu, Ammar M
Yao, Yan
author_sort Zheng, Li-Hui
collection PubMed
description BACKGROUND: Endothelial function, as measured by big endothelin-1 (ET-1), has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease. Nevertheless, there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation (AF). We aimed to investigate the relationship between big ET-1 and CHADS(2)/CHA(2)DS(2)-VASc scores used for evaluating thromboembolic risk in patients with non-valvular AF. METHODS: The study population consisted of 238 consecutive AF patients (67.6% with paroxysmal AF and 32.4% with persistent AF). The patients were divided into two groups (high- or low-intermediate risk group) based on CHADS(2) and CHA(2)DS(2)-VASc scores (score ≥ 2 or < 2, respectively). Clinical, laboratory, and echocardiographic parameters were evaluated, and the CHADS(2/)CHA(2)DS(2)-VASc scores were compared between groups. The association between big ET-1 levels and CHADS(2)/CHA(2)DS(2)-VASc score was assessed. Multivariate logistic regression analysis was performed to identify independent predictors of CHADS(2)/CHA(2)DS(2)-VASc scores. RESULTS: The high CHADS(2)/CHA(2)DS(2)-VASc score group had older age, higher big ET-1 levels, and enlarged left atrial diameter than the low CHADS(2)/CHA(2)DS(2)-VASc score group (P < 0.05). Multiple logistic regression analysis revealed that big ET-1 level was an independent determinant of high CHADS(2)/CHA(2)DS(2)-VASc scores [odds ratio (OR) = 2.545 and OR = 3.816; both P < 0.05]. CONCLUSIONS: Our study indicates that in non-valvular AF, big ET-1 was significantly correlated with CHADS(2)/CHA(2)DS(2)-VASc scores and an independent predictor of high CHADS(2)/CHA(2)DS(2)-VASc scores. Big ET-1 may serve as a useful marker for risk stratification in this setting.
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spelling pubmed-69117982019-12-18 Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation Zheng, Li-Hui Liu, Shang-Yu Hu, Feng Liang, Er-Peng Wu, Ling-Min Wang, Hong-Lei Killu, Ammar M Yao, Yan J Geriatr Cardiol Research Article BACKGROUND: Endothelial function, as measured by big endothelin-1 (ET-1), has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease. Nevertheless, there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation (AF). We aimed to investigate the relationship between big ET-1 and CHADS(2)/CHA(2)DS(2)-VASc scores used for evaluating thromboembolic risk in patients with non-valvular AF. METHODS: The study population consisted of 238 consecutive AF patients (67.6% with paroxysmal AF and 32.4% with persistent AF). The patients were divided into two groups (high- or low-intermediate risk group) based on CHADS(2) and CHA(2)DS(2)-VASc scores (score ≥ 2 or < 2, respectively). Clinical, laboratory, and echocardiographic parameters were evaluated, and the CHADS(2/)CHA(2)DS(2)-VASc scores were compared between groups. The association between big ET-1 levels and CHADS(2)/CHA(2)DS(2)-VASc score was assessed. Multivariate logistic regression analysis was performed to identify independent predictors of CHADS(2)/CHA(2)DS(2)-VASc scores. RESULTS: The high CHADS(2)/CHA(2)DS(2)-VASc score group had older age, higher big ET-1 levels, and enlarged left atrial diameter than the low CHADS(2)/CHA(2)DS(2)-VASc score group (P < 0.05). Multiple logistic regression analysis revealed that big ET-1 level was an independent determinant of high CHADS(2)/CHA(2)DS(2)-VASc scores [odds ratio (OR) = 2.545 and OR = 3.816; both P < 0.05]. CONCLUSIONS: Our study indicates that in non-valvular AF, big ET-1 was significantly correlated with CHADS(2)/CHA(2)DS(2)-VASc scores and an independent predictor of high CHADS(2)/CHA(2)DS(2)-VASc scores. Big ET-1 may serve as a useful marker for risk stratification in this setting. Science Press 2019-11 /pmc/articles/PMC6911798/ /pubmed/31853246 http://dx.doi.org/10.11909/j.issn.1671-5411.2019.11.003 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Article
Zheng, Li-Hui
Liu, Shang-Yu
Hu, Feng
Liang, Er-Peng
Wu, Ling-Min
Wang, Hong-Lei
Killu, Ammar M
Yao, Yan
Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation
title Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation
title_full Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation
title_fullStr Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation
title_full_unstemmed Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation
title_short Association between big endothelin-1 and CHADS(2)/CHA(2)DS(2)-VASc scores in non-valvular atrial fibrillation
title_sort association between big endothelin-1 and chads(2)/cha(2)ds(2)-vasc scores in non-valvular atrial fibrillation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911798/
https://www.ncbi.nlm.nih.gov/pubmed/31853246
http://dx.doi.org/10.11909/j.issn.1671-5411.2019.11.003
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