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Differential involvement of rubral branches in chronic capsular and pontine stroke

BACKGROUND AND PURPOSE: Early studies have indicated that the cortico-rubro-spinal tracts play important roles in motor dysfunction after stroke. However, the differential involvement of the rubral branches in capsular and pontine stroke, and their associations with the motor impairment are still un...

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Autores principales: Guo, Jun, Liu, Jingchun, Wang, Caihong, Cao, Chen, Fu, Lejun, Han, Tong, Cheng, Jingliang, Yu, Chunshui, Qin, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911903/
https://www.ncbi.nlm.nih.gov/pubmed/31835285
http://dx.doi.org/10.1016/j.nicl.2019.102090
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author Guo, Jun
Liu, Jingchun
Wang, Caihong
Cao, Chen
Fu, Lejun
Han, Tong
Cheng, Jingliang
Yu, Chunshui
Qin, Wen
author_facet Guo, Jun
Liu, Jingchun
Wang, Caihong
Cao, Chen
Fu, Lejun
Han, Tong
Cheng, Jingliang
Yu, Chunshui
Qin, Wen
author_sort Guo, Jun
collection PubMed
description BACKGROUND AND PURPOSE: Early studies have indicated that the cortico-rubro-spinal tracts play important roles in motor dysfunction after stroke. However, the differential involvement of the rubral branches in capsular and pontine stroke, and their associations with the motor impairment are still unknown. METHODS: The present study recruited 144 chronic stroke patients and 91 normal controls (NC) from three hospitals, including 102 cases with capsular stroke (CS) and 42 cases with pontine stroke (PS). The rubral branches, including bilateral corticorubral tracts (CRT), dentatorubral tracts (DRT), and rubrospinal tracts (RST), and the cortico-spinal tract (CST) were reconstructed based on the dataset of the Human Connectome Project. Group differences in diffusion scalars of each rubral branch were compared, and the associations between the diffusion measures of rubral branches and the Fugl-Meyer assessment (FMA) scores were tested. RESULTS: The bilateral CRT of the CS cases showed significantly lower factional anisotropy (FA) than in the NC. The bilateral DRT of the PS cases had lower FA than in the NC. Both CS and PS cases had significantly lower FA of the bilateral RST than the NC. Besides, the stroke patients demonstrated significantly lower FA in bilateral CSTs than the NC. Partial correlation analysis identified significantly positive correlations between the FA of the ipsilesional and CRT and the FMA scores in the CS group, and significantly positive correlations between the FA of the RST bilaterally and the FMA scores in the CS and PS groups. Furthermore, the association between RST integrity and FMA scores still survived after controlling for the effect of the CST. Finally, multiple regression modelling found that rubral tract FA explained 39.2% of the variance in FMA scores for CS patients, and 48.8% of the variance in FMA scores for PS patients. CONCLUSIONS: The bilateral rubral branches were differentially involved in the chronic capsular and pontine stroke, and the impairment severity of each rubral branch was dependent on lesion locations. The integrity of the rubral branches is related to motor impairment in both the chronic capsular and pontine stroke.
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spelling pubmed-69119032019-12-23 Differential involvement of rubral branches in chronic capsular and pontine stroke Guo, Jun Liu, Jingchun Wang, Caihong Cao, Chen Fu, Lejun Han, Tong Cheng, Jingliang Yu, Chunshui Qin, Wen Neuroimage Clin Regular Article BACKGROUND AND PURPOSE: Early studies have indicated that the cortico-rubro-spinal tracts play important roles in motor dysfunction after stroke. However, the differential involvement of the rubral branches in capsular and pontine stroke, and their associations with the motor impairment are still unknown. METHODS: The present study recruited 144 chronic stroke patients and 91 normal controls (NC) from three hospitals, including 102 cases with capsular stroke (CS) and 42 cases with pontine stroke (PS). The rubral branches, including bilateral corticorubral tracts (CRT), dentatorubral tracts (DRT), and rubrospinal tracts (RST), and the cortico-spinal tract (CST) were reconstructed based on the dataset of the Human Connectome Project. Group differences in diffusion scalars of each rubral branch were compared, and the associations between the diffusion measures of rubral branches and the Fugl-Meyer assessment (FMA) scores were tested. RESULTS: The bilateral CRT of the CS cases showed significantly lower factional anisotropy (FA) than in the NC. The bilateral DRT of the PS cases had lower FA than in the NC. Both CS and PS cases had significantly lower FA of the bilateral RST than the NC. Besides, the stroke patients demonstrated significantly lower FA in bilateral CSTs than the NC. Partial correlation analysis identified significantly positive correlations between the FA of the ipsilesional and CRT and the FMA scores in the CS group, and significantly positive correlations between the FA of the RST bilaterally and the FMA scores in the CS and PS groups. Furthermore, the association between RST integrity and FMA scores still survived after controlling for the effect of the CST. Finally, multiple regression modelling found that rubral tract FA explained 39.2% of the variance in FMA scores for CS patients, and 48.8% of the variance in FMA scores for PS patients. CONCLUSIONS: The bilateral rubral branches were differentially involved in the chronic capsular and pontine stroke, and the impairment severity of each rubral branch was dependent on lesion locations. The integrity of the rubral branches is related to motor impairment in both the chronic capsular and pontine stroke. Elsevier 2019-11-12 /pmc/articles/PMC6911903/ /pubmed/31835285 http://dx.doi.org/10.1016/j.nicl.2019.102090 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Guo, Jun
Liu, Jingchun
Wang, Caihong
Cao, Chen
Fu, Lejun
Han, Tong
Cheng, Jingliang
Yu, Chunshui
Qin, Wen
Differential involvement of rubral branches in chronic capsular and pontine stroke
title Differential involvement of rubral branches in chronic capsular and pontine stroke
title_full Differential involvement of rubral branches in chronic capsular and pontine stroke
title_fullStr Differential involvement of rubral branches in chronic capsular and pontine stroke
title_full_unstemmed Differential involvement of rubral branches in chronic capsular and pontine stroke
title_short Differential involvement of rubral branches in chronic capsular and pontine stroke
title_sort differential involvement of rubral branches in chronic capsular and pontine stroke
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911903/
https://www.ncbi.nlm.nih.gov/pubmed/31835285
http://dx.doi.org/10.1016/j.nicl.2019.102090
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